INT171021

Context Info Confidence 0.41 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 18 Total Number 19 Disease Relevance 14.74 Pain Relevance 3.39

extracellular space (IL5) extracellular region (IL5)

Anatomy Link Frequency eosinophil 4 blood 2 granulocytes 1 epithelial cell 1 Th2 cells 1 IL5 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 595 100.00 antagonist 183 100.00 Inflammation 1011 99.92 withdrawal 17 94.04 antiepileptic Drug 1 86.72 aspirin 5 85.44 corticosteroid 57 85.28 chemokine 158 82.80 carbamazepine 29 82.56 Inflammatory mediators 30 74.96

Disease Link Frequency Relevance Heat INFLAMMATION 1101 99.92 Disease 294 99.90 Rhinitis 127 99.66 Asthma 1912 99.44 Chronic Sinusitis 71 99.28 Hypersensitivity 107 98.82 Adhesions 34 98.72 Cancer 29 98.20 Eosinophilia 173 97.98 Pulmonary Disease 415 96.92

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Anatomy

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Disease term

It is interesting that Liu and colleagues later showed a marked reduction in the expression of messenger ribonucleic acid of the surface IL-5 receptor (mIL-5R?)

Negative_regulation (reduction) of IL-5

1) Confidence 0.41 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.41 Pain Relevance 0

In recent studies RNA interference using a short hairpin RNA, has been able to block IL-5R?

Negative_regulation (block) of IL-5

2) Confidence 0.41 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.96 Pain Relevance 0.18

Inhalation of low dose CO in an ovalbumin-induced allergic in vivo model attenuates the eosinophilic inflammation by reducing IL-5 levels, and reduces bronchial hyperresponsiveness to methacholine (Figure 4).

Negative_regulation (reducing) of IL-5 associated with rhinitis, inflammation and hypersensitivity

3) Confidence 0.36 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 1.11 Pain Relevance 0.33

Senel et al [14] reported a combination of cyclosporine, azathioprine and prednisolone to be successful in treatment of KD and decreasing serum levels of soluble IL-2 receptor (sIL-2R), IL-4 and IL-5 consequently.

Negative_regulation (decreasing) of IL-5 associated with disease

4) Confidence 0.27 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.49 Pain Relevance 0.09

They also showed a decrease in serum levels of sIL-2R, IL-4, IL-5, IgE and eosinophil count.

Negative_regulation (decrease) of IL-5 in eosinophil

5) Confidence 0.27 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.48 Pain Relevance 0.11

However, a decrease of soluble interleukin-5 receptor alpha in the resolution phase of a virus-induced exacerbation has been related to an increase in FEV1, suggesting that such a relationship may exist (Rohdeet al 2004).

Negative_regulation (decrease) of interleukin-5

6) Confidence 0.27 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 0.46 Pain Relevance 0.08

Inhibition of cytokines involved in the recruitment of eosinophils, such as IL-5, RANTES, and eotaxin could also be a strategy to modify inflammation during COPD exacerbations.

Negative_regulation (Inhibition) of IL-5 in eosinophils associated with pulmonary disease, inflammation and cytokine

7) Confidence 0.26 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 1.69 Pain Relevance 0.36

Glucocorticoids decrease the levels of IL-5, which is one of the major growth factors for eosinophilic granulocytes (especially in eosinophilic conditions).

Negative_regulation (decrease) of IL-5 in granulocytes associated with rhinitis

8) Confidence 0.25 Published 2008 Journal Cases J Section Body Doc Link PMC2596115 Disease Relevance 0.90 Pain Relevance 0.23

However, the IL-5 response was reduced in S. stercoralis and HTLV-1 co-infected patients (10 vs 299 pg/ml respectively, p?

Negative_regulation (reduced) of IL-5

9) Confidence 0.25 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.17 Pain Relevance 0.04

We reasoned that regulatory T cells might be responsible for the reduced IL-5 and eosinophil responses in S. stercoralis and HTLV-1 co-infected patients.

Negative_regulation (reduced) of IL-5 in eosinophil

10) Confidence 0.25 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.28 Pain Relevance 0

A 19-amino acid peptide that binds to the IL-5 receptor alpha/beta heterodimer complex, with an affinity equal to that of IL-5, has been shown to be a potent and specific antagonist of IL-5 activity in a human eosinophil adhesion assay [67].

Negative_regulation (antagonist) of IL-5 in eosinophil associated with antagonist and adhesions

11) Confidence 0.19 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.00 Pain Relevance 0.86

High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.

Negative_regulation (decreased) of IL-5 in blood

12) Confidence 0.12 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.79 Pain Relevance 0.15

Also, in an animal model of asthma, treatment with pranlukast reduces IL-5 but has no effect on IFN-?

Negative_regulation (reduces) of IL-5 associated with asthma

13) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.76 Pain Relevance 0.41

It is possible that the persistent airway wall eosinophilia in this situation reflected an inhibitory effect on trans-epithelial cell migration by the antibody blocking interleukin-5.

Negative_regulation (blocking) of interleukin-5 in epithelial cell associated with eosinophilia

14) Confidence 0.11 Published 2010 Journal Respir Res Section Body Doc Link PMC2900258 Disease Relevance 0.84 Pain Relevance 0.06

, and to suppress Th2 cytokine genes such as IL-4 and IL-5 in Th2 cells [148,149].

Negative_regulation (suppress) of IL-5 in Th2 cells associated with cytokine

15) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.18 Pain Relevance 0.17

Additionally, the BTPs show inhibition of IL-4, IL-5, IL-8, and CCL11 production [150,151].

Negative_regulation (inhibition) of IL-5

16) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.27 Pain Relevance 0.16

These findings correlated with decreased levels of IL-4 and IL-5 in the airways in NES-treated animals [316].

Negative_regulation (decreased) of IL-5

17) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.11 Pain Relevance 0

Giving an antibody to block interleukin-5, a regulator of eosinophilopoiesis, eosinophil migration, and eosinophil survival, eliminated both blood and airway lumen eosinophilia [102] but had little effect on airway wall eosinophils [103], and no pro-apoptotic effect has been demonstrated.

Negative_regulation (block) of interleukin-5 in blood associated with apoptosis and eosinophilia

18) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC2900258 Disease Relevance 1.08 Pain Relevance 0.07

After the FESS, the levels of specific IgE, IL-4 and IL-5 were attenuated significantly in CRS-asthma patients, but not in asthma alone patients.

Negative_regulation (attenuated) of IL-5 associated with asthma and chronic sinusitis

19) Confidence 0.02 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1524974 Disease Relevance 1.77 Pain Relevance 0.09

General Comments

This test has worked.