INT171023

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.53
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CCR1) plasma membrane (CCR1) cell-cell signaling (CCR1)
signal transducer activity (CCR1)
Anatomy Link Frequency
connective tissue 2
CCR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 7 99.98 Very High Very High Very High
cytokine 97 99.62 Very High Very High Very High
Inflammation 135 77.64 Quite High
chemokine 46 68.00 Quite High
psoriasis 44 24.20 Low Low
rheumatoid arthritis 88 7.52 Low Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
Arthritis 26 5.00 Very Low Very Low Very Low
Inflammatory mediators 14 5.00 Very Low Very Low Very Low
antagonist 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 4 96.68 Very High Very High Very High
Systemic Sclerosis 34 92.00 High High
Asthma 41 83.00 Quite High
INFLAMMATION 156 77.64 Quite High
Diffuse Scleroderma 1 73.68 Quite High
Limited Scleroderma 1 69.44 Quite High
Adhesions 11 67.64 Quite High
Injury 3 52.48 Quite High
Autoimmune Disease 33 50.00 Quite Low
Disease 74 38.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of the cells with dexamethasone inhibited expression of RANTES mRNA and inhibited secretion of RANTES protein.
Negative_regulation (inhibited) of Gene_expression (expression) of RANTES mRNA associated with dexamethasone
1) Confidence 0.37 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.41 Pain Relevance 0.26
Cytokine or cytokine receptor patterns showed high expression of CCR1, FGFR1, connective tissue growth factor (CTGF), FGF7, and SCYA19 in biopsies from SSC patients.
Negative_regulation (showed) of Gene_expression (expression) of CCR1 in connective tissue associated with hypersensitivity and cytokine
2) Confidence 0.14 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.11 Pain Relevance 0.10

General Comments

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