INT17103

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Context Info
Confidence 0.38
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 4.95
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
nucleus accumbens 2
striatum 2
RVLM 1
adult brain 1
pituitary 1
Prep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 471 100.00 Very High Very High Very High
Nerve growth factor 6 100.00 Very High Very High Very High
Nucleus accumbens 12 99.76 Very High Very High Very High
local anesthetic 4 99.76 Very High Very High Very High
Pain 199 99.24 Very High Very High Very High
Rostral ventrolateral medulla 9 97.50 Very High Very High Very High
anesthesia 12 96.32 Very High Very High Very High
Opioid 1 96.20 Very High Very High Very High
Enkephalin 13 92.80 High High
alcohol 8 87.36 High High
Disease Link Frequency Relevance Heat
Aging 33 99.56 Very High Very High Very High
Pain 215 99.24 Very High Very High Very High
Pressure Volume 2 Under Development 1 98.14 Very High Very High Very High
Stress 112 97.94 Very High Very High Very High
Disorder Of Lipid Metabolism 20 94.32 High High
Body Weight 22 90.52 High High
Poisoning 3 90.20 High High
Parkinson's Disease 1 85.20 High High
Nociception 22 83.28 Quite High
Overdose 4 83.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aging was accompanied by a loss of PE peptide and PE mRNA in the rostral striatum.
Negative_regulation (loss) of PE peptide in striatum associated with aging
1) Confidence 0.38 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9726289 Disease Relevance 0.56 Pain Relevance 0.27
In aged rats, PE mRNA was also reduced in the shell region of the nucleus accumbens.
Negative_regulation (reduced) of PE mRNA in nucleus accumbens associated with nucleus accumbens
2) Confidence 0.38 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9726289 Disease Relevance 0.62 Pain Relevance 0.28
Aging was accompanied by a loss of PE peptide and PE mRNA in the rostral striatum.
Negative_regulation (loss) of PE mRNA in striatum associated with aging
3) Confidence 0.38 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9726289 Disease Relevance 0.61 Pain Relevance 0.27
The decline in PE mRNA in the rostral striatum and shell region of the nucleus accumbens was caused by a reduction in the number of cells that contain PE mRNA.
Negative_regulation (decline) of PE mRNA in nucleus accumbens associated with nucleus accumbens
4) Confidence 0.33 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9726289 Disease Relevance 0.68 Pain Relevance 0.28
Hypophysectomy prior to the onset of puberty was found to drastically reduce the level of PE mRNA in the testis and epididymus, suggesting that pituitary factors affect the expression of the PE gene in these tissues, either directly or indirectly.
Negative_regulation (reduce) of PE mRNA in pituitary
5) Confidence 0.26 Published 1990 Journal NIDA Res. Monogr. Section Abstract Doc Link 1875991 Disease Relevance 0 Pain Relevance 0.17
Because both the PE and NGF genes showed developmental downregulation, we asked whether we could prepare reactive astrocytes from lesioned adult brain and see expression turned back on.
Negative_regulation (downregulation) of PE in adult brain associated with nerve growth factor
6) Confidence 0.05 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7532097 Disease Relevance 0.16 Pain Relevance 0.42
In Sprague-Dawley rats maintained under propofol anesthesia, microinjection bilaterally of Mev (10 nmol) into the RVLM induced progressive hypotension that was accompanied by an early augmentation (80-100 min post-Mev; Phase I), followed by a decrease (>100 min post-Mev; Phase II) in the power density of the vasomotor components (0-0.8 Hz) in systemic arterial pressure (SAP) signals.
Negative_regulation (decrease) of post-Mev in RVLM associated with rostral ventrolateral medulla, anesthesia and pressure volume 2 under development
7) Confidence 0.03 Published 2004 Journal Shock Section Abstract Doc Link 15179137 Disease Relevance 0.48 Pain Relevance 0.41
Post perfusion artifacts were prevented by
Negative_regulation (prevented) of Post
8) Confidence 0.03 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1975761 Disease Relevance 0.35 Pain Relevance 0.04
Compared to those of control group, the triglyceride level was significantly low in vitamin B6 deficient rats regardless of exercise and the tendency of decrease in post-exercise and recess after exercise was similar in both control and B6- groups.
Negative_regulation (decrease) of post-exercise
9) Confidence 0.03 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2808720 Disease Relevance 0.17 Pain Relevance 0
Patients receiving intraarticular injections of local anesthetics before the POST block did not differ in pain ratings and neurophysiological parameters from patients not receiving this treatment.
Negative_regulation (block) of POST associated with pain and local anesthetic
10) Confidence 0.03 Published 2008 Journal Journal of pain research Section Body Doc Link PMC3004616 Disease Relevance 0.35 Pain Relevance 0.34
The SOD activity of control group remained stable with exercise-induced oxidative stress but the SOD activity of vitamin B6 deficient groups was decreased with exercise and was significantly lower in post-exercise and recess after exercise.
Negative_regulation (lower) of post-exercise associated with stress
11) Confidence 0.03 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2808720 Disease Relevance 0.42 Pain Relevance 0
Finally a last block (POST) was performed after complete relief of pain.
Negative_regulation (block) of POST associated with pain
12) Confidence 0.03 Published 2008 Journal Journal of pain research Section Body Doc Link PMC3004616 Disease Relevance 0.55 Pain Relevance 0.73
We found that the number of SOM-ir cells in the PeVN was also affected by the time following ovariectomy.
Negative_regulation (number) of PeVN associated with somatostatin
13) Confidence 0.02 Published 2008 Journal Exp Brain Res Section Body Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.54
To facilitate the assessment of radioactivity in the olfactory submucosa and to prevent potential post-mortem tracer contamination from the CSF compartment, the turbinates were cut from frozen tissue.
Negative_regulation (prevent) of post-mortem in olfactory
14) Confidence 0.02 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0 Pain Relevance 0
In contrast, SOM mRNA levels in the PeVN also decrease following OVX, but this reduction can be reversed by treatment with E2 (Bethea et al. 1992; Werner et al. 1988; Zorilla et al. 1990).
Negative_regulation (decrease) of PeVN associated with somatostatin
15) Confidence 0.02 Published 2008 Journal Exp Brain Res Section Body Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.46
Insert: total (sections 1–9) number of SOM-ir cells in the PeVN was significantly higher in long-term compared with short-term OVX + E2 rats.
Negative_regulation (number) of PeVN in sections 1 associated with somatostatin
16) Confidence 0.02 Published 2008 Journal Exp Brain Res Section Body Doc Link PMC2441535 Disease Relevance 0 Pain Relevance 0.50

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