INT171032

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 8.94
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SMPD1) extracellular space (SMPD1) small molecule metabolic process (SMPD1)
hydrolase activity, acting on glycosyl bonds (SMPD1) cell death (SMPD1)
Anatomy Link Frequency
SW480 1
lumen 1
epithelium 1
goblet cell 1
thickening 1
SMPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
b2 receptor 5 100.00 Very High Very High Very High
agonist 300 98.82 Very High Very High Very High
bradykinin 56 96.84 Very High Very High Very High
cytokine 205 96.64 Very High Very High Very High
Catecholamine 18 90.40 High High
Inflammation 406 90.24 High High
COX-2 inhibitor 156 90.20 High High
adenocard 40 85.76 High High
Kinase C 90 81.60 Quite High
cINOD 60 71.08 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 16 99.90 Very High Very High Very High
Asthma 338 99.60 Very High Very High Very High
Apoptosis 462 99.28 Very High Very High Very High
Hypertrophy 12 99.20 Very High Very High Very High
Death 81 98.84 Very High Very High Very High
Hyperplasia 12 98.36 Very High Very High Very High
Colon Cancer 69 98.00 Very High Very High Very High
Common Cold 5 95.76 Very High Very High Very High
Airway Remodeling 49 94.24 High High
Occupational Lung Diseases 54 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exacerbating this condition in asthma is the sloughing of airway epithelium, which constitutes a loss of diffusion barrier and may increase ASM access preferentially to procontractile agonists [152,160,161].
Positive_regulation (increase) of ASM in epithelium associated with asthma and agonist
1) Confidence 0.12 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.62 Pain Relevance 0.36
These findings strongly suggest that exaggerated procontractile GPCR agonist presentation to ASM occurs with asthma and contributes to increased ASM tone.
Positive_regulation (increased) of ASM associated with asthma and agonist
2) Confidence 0.12 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.63 Pain Relevance 0.42
Excessive mucous production and edema are physical impediments to conductance, whereas edema and increased ASM mass alter airway geometry to amplify the effect of ASM contraction on airway lumen diameter [148-154].
Positive_regulation (increased) of ASM in lumen associated with pressure and volume under development
3) Confidence 0.12 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.49 Pain Relevance 0.21
-glutamyl transpeptidase) by ASM has also been reported following exposure of ASM cells to atopic serum or IL-1?
Positive_regulation (reported) of ASM
4) Confidence 0.09 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.55 Pain Relevance 0.24
Other ASM Gq-coupled receptors capable of inducing significant ASM contraction (in vivo or ex vivo) include the H1 histamine receptor, CLT1R, B2 bradykinin receptors, and ET-A endothelin receptor.
Positive_regulation (inducing) of ASM associated with bradykinin
5) Confidence 0.08 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.22
Important structural changes of inflamed airways include epithelial cell shedding, basement membrane thickening, goblet cell hyperplasia (increase in cell number) and hypertrophy (increase in cell size), as well as an increase in airway smooth muscle (ASM) content [2].
Positive_regulation (increase) of ASM in thickening associated with hypertrophy and hyperplasia
6) Confidence 0.08 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.03 Pain Relevance 0.22
are both able to increase B2 bradykinin receptor expression in ASM [174,175].
Positive_regulation (increase) of ASM associated with b2 receptor
7) Confidence 0.07 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.27 Pain Relevance 0.18
Important structural changes of inflamed airways include epithelial cell shedding, basement membrane thickening, goblet cell hyperplasia (increase in cell number) and hypertrophy (increase in cell size), as well as an increase in airway smooth muscle (ASM) content [2].
Positive_regulation (increase) of ASM in goblet cell associated with hypertrophy and hyperplasia
8) Confidence 0.03 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.03 Pain Relevance 0.22
Sulindac sulphide, a metabolite of sulindac, also activates sphingomyelinase and enhances the ceramide level in the two human colorectal carcinoma cell lines HCT116 and SW480 [106].
Positive_regulation (activates) of sphingomyelinase in SW480 associated with colon cancer
9) Confidence 0.01 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.50 Pain Relevance 0.17
This effect was due to an accumulation of arachidonic acid inside the cells, which activates sphingomyelinase, triggering a clustering of death receptor (DR) 5 receptors in ceramide and cholesterol-rich domains [119].
Positive_regulation (activates) of sphingomyelinase associated with death
10) Confidence 0.01 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.31 Pain Relevance 0.12
Accumulation of arachidonic acid can affect apoptosis by mediating an increase of pro-apoptotic intra-cellular ceramides caused by activation of sphingomyelinase [104, 105].
Positive_regulation (activation) of sphingomyelinase associated with apoptosis
11) Confidence 0.01 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.50 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox