INT171037

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL8) extracellular space (CCL8) extracellular region (CCL8)
cell-cell signaling (CCL8)
Anatomy Link Frequency
immune cells 1
CCL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 45 100.00 Very High Very High Very High
chemokine 31 100.00 Very High Very High Very High
Inflammation 95 97.96 Very High Very High Very High
dexamethasone 7 78.64 Quite High
Inflammatory mediators 10 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 98.72 Very High Very High Very High
INFLAMMATION 118 97.96 Very High Very High Very High
Asthma 44 97.52 Very High Very High Very High
Atherosclerosis 9 69.68 Quite High
Hypersensitivity 3 48.96 Quite Low
Stress Incontinence 4 20.40 Low Low
Injury 9 18.84 Low Low
Heart Rate Under Development 1 17.92 Low Low
Pressure Volume 2 Under Development 1 17.40 Low Low
Cancer 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arterial SMCs, in particular, express a large set of genes that mediate these interactions—such as cytokines/chemokines (IL6, CCL8, CCL7, CCL2, CXCL1, CXCL2, CXCL3, and CXCL6), complement pathway (complement factor B [CFB]), and surface receptor (ICAM1) (Figure 3B)—suggesting that vascular SMCs may themselves mediate recruitment of immune cells to the vascular walls.
Gene_expression (express) of CCL8 in immune cells associated with chemokine and cytokine
1) Confidence 0.45 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.17 Pain Relevance 0.10
Work published by two groups describes the expression and secretion of MCP-1, MCP-2 and MCP-3 by human ASM cells treated with the pro-inflammatory cytokines TNF-?
Gene_expression (expression) of MCP-2 associated with inflammation and cytokine
2) Confidence 0.04 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.25 Pain Relevance 0.32

General Comments

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