INT171058

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 9.31
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDX1) generation of precursor metabolites and energy (PDX1) nucleus (PDX1)
cytoplasm (PDX1)
Anatomy Link Frequency
lungs 4
respiratory 2
PDX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1108 100.00 Very High Very High Very High
metalloproteinase 9 67.76 Quite High
cva 3 66.04 Quite High
Inflammation 87 63.80 Quite High
corticosteroid 30 25.52 Quite Low
alcohol 4 13.16 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Idiopathic Pulmonary Fibrosis 1045 100.00 Very High Very High Very High
Pulmonary Fibrosis 115 100.00 Very High Very High Very High
Pulmonary Disease 280 99.36 Very High Very High Very High
Cicatrix 9 96.68 Very High Very High Very High
Respiratory Failure 3 95.48 Very High Very High Very High
Disease 175 93.20 High High
Dyspnea 21 89.92 High High
Nicotine Addiction 57 86.48 High High
Increased Venous Pressure Under Development 9 78.56 Quite High
Acid Base Imbalance 3 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The development of AE-IPF in patients without known IPF can be recognized when consensus criteria for IPF (see below) are satisfied and the patient presents with acute respiratory failure.
Negative_regulation (development) of IPF in respiratory associated with fibrosis and respiratory failure
1) Confidence 0.32 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 2.16 Pain Relevance 0.72
Gas exchange is impaired in IPF which can be demonstrated by measurement of the diffusion capacity.
Negative_regulation (impaired) of IPF associated with fibrosis
2) Confidence 0.32 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 0.96 Pain Relevance 0.23
The development of AE-IPF in patients without known IPF can be recognized when consensus criteria for IPF (see below) are satisfied and the patient presents with acute respiratory failure.
Negative_regulation (development) of AE-IPF in respiratory associated with fibrosis and respiratory failure
3) Confidence 0.32 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 2.09 Pain Relevance 0.69
For this reason, it has been proposed that a non-degradative lung microenvironment prevails in IPF, which enhances the progressive accumulation of fibrillar collagens [46].
Negative_regulation (prevails) of IPF in lung associated with fibrosis
4) Confidence 0.07 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 0.52 Pain Relevance 0.27
monomers but also their complexes in human lungs, whereas decline in IPF was most significant in the Hb?
Negative_regulation (decline) of IPF in lungs associated with fibrosis
5) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.82 Pain Relevance 0.11
Two highly abundant "spot trains" at 15 kDa and two spots at a higher molecular mass in the 2-D gels of all control lungs could be detected, which were absent or considerably reduced in the IPF lungs (Figure 1).
Negative_regulation (reduced) of IPF in lungs associated with fibrosis
6) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.04 Pain Relevance 0.30
The levels of Hb complexes declined only in IPF for reasons that remain unclear.
Negative_regulation (declined) of IPF associated with fibrosis
7) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.62 Pain Relevance 0.15
Decline of Hb complexes and monomers in the IPF but not in the COPD lungs
Negative_regulation (Decline) of IPF in lungs associated with fibrosis and pulmonary disease
8) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.12 Pain Relevance 0.24

General Comments

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