INT171059

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.70
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDX1) generation of precursor metabolites and energy (PDX1) nucleus (PDX1)
cytoplasm (PDX1)
Anatomy Link Frequency
epithelial cells 2
precursor cells 1
PDX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 624 100.00 Very High Very High Very High
Inflammation 96 90.48 High High
palliative 4 87.44 High High
corticosteroid 13 61.16 Quite High
cINOD 3 59.88 Quite High
addiction 6 59.08 Quite High
cytokine 13 51.16 Quite High
Pain 6 33.04 Quite Low
chemokine 4 20.20 Low Low
Inflammatory response 2 10.48 Low Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 338 100.00 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 284 100.00 Very High Very High Very High
Lung Injury 9 99.92 Very High Very High Very High
Fibrosis 113 99.68 Very High Very High Very High
Interstitial Lung Diseases 94 99.36 Very High Very High Very High
Fatigue 4 99.14 Very High Very High Very High
Apoptosis 42 96.96 Very High Very High Very High
Necrosis 10 94.60 High High
Cough 12 93.72 High High
Dyspnea 26 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fatigue, or more precisely, exhaustion is another effect of IPF that patients mention as occurring frequently and negatively impacting their lives.
Localization (effect) of IPF associated with fibrosis and fatigue
1) Confidence 0.56 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1276807 Disease Relevance 1.30 Pain Relevance 0.42
The "typical" appearance of IPF on HRCT consists of patchy, predominantly peripheral, predominantly subpleural and necessarily bibasilar reticular opacification (Figure 2).
Localization (appearance) of IPF associated with fibrosis
2) Confidence 0.53 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 0.87 Pain Relevance 0.16
In fact, during pancreatic development, differentiated cells derive from the PDX-1+ ductal precursor cells: consequently, colocalization of c-kit/PDX-1 could coincide with endocrine ?
Localization (colocalization) of PDX-1 in precursor cells
3) Confidence 0.44 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
The other is the 'epithelial/fibroblastic route', which is represented by IPF.
Localization (represented) of IPF associated with fibrosis
4) Confidence 0.13 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 1.66 Pain Relevance 0.69
For example, we have demonstrated that altered fibroblasts emerging during fibrotic lung injury in IPF release angiotensin peptides and perhaps other soluble factors capable of inducing programmed cell death and net loss of alveolar epithelial cells [23,24].
Localization (release) of IPF in epithelial cells associated with lung injury, fibrosis and apoptosis
5) Confidence 0.12 Published 2002 Journal Respir Res Section Body Doc Link PMC64814 Disease Relevance 1.60 Pain Relevance 0.14
The question remains whether FVC and DLco are useful as surrogate markers for survival in trials searching for therapeutic strategy in IPF?
Localization (strategy) of IPF
6) Confidence 0.11 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 0.06 Pain Relevance 0
What is needed now, to complement and operationalise the GSF, is an individualised prognostic "marker" to help initiate these vital conversations about prognosis and EOL care.
Localization (operationalise) of GSF
7) Confidence 0.05 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2913927 Disease Relevance 0.49 Pain Relevance 0.17
This is also supported by the colocalization of MMP-7 and osteopontin in IPF epithelial cells, and by the computational relationship of the expression levels of osteopontin and MMP-7.
Localization (colocalization) of IPF in epithelial cells associated with fibrosis
8) Confidence 0.04 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.71 Pain Relevance 0.33

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