INT171060

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 72
Total Number 75
Disease Relevance 72.57
Pain Relevance 17.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDX1) generation of precursor metabolites and energy (PDX1) nucleus (PDX1)
cytoplasm (PDX1)
Anatomy Link Frequency
lungs 16
epithelial cells 6
connective tissue 4
stage 4 3
precursor cells 2
PDX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 6467 100.00 Very High Very High Very High
Inflammation 499 99.44 Very High Very High Very High
corticosteroid 236 99.36 Very High Very High Very High
cva 17 95.28 Very High Very High Very High
rheumatoid arthritis 34 94.48 High High
cytokine 80 93.40 High High
Spinal cord 21 89.96 High High
Inflammatory response 16 88.12 High High
spinal inflammation 17 83.96 Quite High
Angina 10 62.80 Quite High
Disease Link Frequency Relevance Heat
Idiopathic Pulmonary Fibrosis 4936 100.00 Very High Very High Very High
Pulmonary Fibrosis 1745 100.00 Very High Very High Very High
Pulmonary Disease 709 100.00 Very High Very High Very High
Bronchiolitis Obliterans Organizing Pneumonia 545 100.00 Very High Very High Very High
Apoptosis 154 100.00 Very High Very High Very High
Secondary Pulmonary Hypertension 153 100.00 Very High Very High Very High
Hyperplasia 46 99.92 Very High Very High Very High
Pneumonia 122 99.84 Very High Very High Very High
Rheumatoid Arthritis 221 99.82 Very High Very High Very High
Motor Neuron Diseases 198 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All of them expressed transcription factors pax-6, pdx 1, and isl-1 (Figure 2).
Gene_expression (expressed) of pdx 1
1) Confidence 0.75 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.21 Pain Relevance 0.03
Thus, tissues derived from neural progenitor cells express insulin, Pdx1, and FoxA3, markers typically co-expressed in foregut-derived tissues.
Gene_expression (co-expressed) of Pdx1 in foregut
2) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.36 Pain Relevance 0
We were unable to detect expression of Pdx1 and FoxA3 using immunohistochemical methods in stage 4 IPCs, (data not shown).
Gene_expression (expression) of Pdx1 in stage 4
3) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.30 Pain Relevance 0
Pdx1, Cdx1, and FoxA3 expression was induced in “stage 3,” when cell clusters were allowed to adhere to pre-coated wells at a density of 40–80 NSs/cm2 and cultured in low-glucose medium with 2 ?
Gene_expression (expression) of Pdx1 in stage 3
4) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.99 Pain Relevance 0
Thus, tissues derived from neural progenitor cells express insulin, Pdx1, and FoxA3, markers typically co-expressed in foregut-derived tissues.
Gene_expression (express) of Pdx1 in foregut
5) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.36 Pain Relevance 0
To investigate whether RA could stimulate development of NS-derived cells toward an IPC fate, we measured expression of Pdx1, Cdx1, and FoxA3, transcription factors that regulate gastrointestinal organ development [29,30].
Gene_expression (expression) of Pdx1 associated with rheumatoid arthritis
6) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.88 Pain Relevance 0
Coinciding with the onset of high insulin expression levels in mouse islets, ngn3 expression is virtually extinguished [25], while expression of Pdx1, FoxA3, Isl1, and Nkx6.1 in islet ?
Gene_expression (expression) of Pdx1 associated with hyperinsulinism
7) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.33 Pain Relevance 0
Moreover, Shh treatment during stage 4 eliminated expression of Pdx1, FoxA3, and insulin (Figure 3F).
Gene_expression (expression) of Pdx1 in stage 4
8) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.13 Pain Relevance 0
Similarly, we noted that IPC maturation from stage 3 to 4 was accompanied by increased insulin expression, reduced ngn3 expression, and increased or maintained levels of Isl1, FoxA3, and Pdx1 expression (see Figure 1B and 1C).
Gene_expression (expression) of Pdx1 in stage 3 associated with hyperinsulinism
9) Confidence 0.61 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.37 Pain Relevance 0
To elucidate the mechanisms underlying RA-induced expression of markers like FoxA3 and Pdx1, we examined Hh signaling during IPC development.
Gene_expression (expression) of Pdx1 associated with rheumatoid arthritis
10) Confidence 0.53 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.28 Pain Relevance 0.04
To test directly whether the absence of Hh signaling was required for expression of endodermal or islet markers, including FoxA3, Pdx1, and insulin, we added Shh protein to stage 4 cultures, which do not express Shh or genes encoding other Hh ligands like Desert hedgehog or Indian hedgehog (Figure 3C).
Gene_expression (expression) of Pdx1 in stage 4
11) Confidence 0.53 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.20 Pain Relevance 0.03
Acute exacerbations of IPF
Gene_expression (exacerbations) of IPF associated with fibrosis
12) Confidence 0.51 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.48 Pain Relevance 0.51
According to guidelines, the diagnosis of IPF can be considered definitive only in the presence of a surgical (not transbronchial) lung biopsy.
Gene_expression (diagnosis) of IPF in lung associated with fibrosis
13) Confidence 0.51 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.90 Pain Relevance 0.38
IPF is typically progressive and leads to significant disability.
Gene_expression (progressive) of IPF associated with fibrosis
14) Confidence 0.51 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2330030 Disease Relevance 1.83 Pain Relevance 0.42
This study found that the prevalence of IPF was only 2.7 cases per 100,000 amongst those aged 35 to 44 years-old; meanwhile, 175 cases per 100,000 were found among persons over the age of 75 years.
Gene_expression (prevalence) of IPF associated with fibrosis
15) Confidence 0.51 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.54 Pain Relevance 0.61
It is estimated that IPF affects at least 5 million persons worldwide.
Gene_expression (affects) of IPF associated with fibrosis
16) Confidence 0.51 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.79 Pain Relevance 0.53
The definite diagnosis of IPF requires all of the following: [1]

• Surgical lung biopsy revealing a histologic pattern consistent with UIP • Exclusion of other known causes of interstitial lung disease (e.g.: connective tissue disease, environmental exposure, etc.) • Abnormal pulmonary physiology with evidence of restriction and/or impaired gas exchange (can exist during exercise alone) • HRCT demonstrating a pattern of "confident" or "possible" IPF.

Gene_expression (diagnosis) of IPF in connective tissue associated with fibrosis, interstitial lung diseases, idiopathic pulmonary fibrosis and disease
17) Confidence 0.51 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.85 Pain Relevance 0.41
Acute exacerbations can occur in patients with known IPF, but AE-IPF also presents as the initial manifestation of IPF [26].
Gene_expression (manifestation) of IPF associated with fibrosis
18) Confidence 0.51 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.80 Pain Relevance 0.63
The "typical" appearance of IPF on HRCT consists of patchy, predominantly peripheral, predominantly subpleural and necessarily bibasilar reticular opacification (Figure 2).
Gene_expression (appearance) of IPF associated with fibrosis
19) Confidence 0.51 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 0.87 Pain Relevance 0.16
Thus in the right clinical setting, it is possible to make the diagnosis of IPF by HRCT alone.
Gene_expression (diagnosis) of IPF associated with fibrosis
20) Confidence 0.51 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 2.45 Pain Relevance 0.38

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