INT171070

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Context Info
Confidence 0.05
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 10.12
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hey2) protein binding transcription factor activity (Hey2) DNA binding (Hey2)
transcription factor binding (Hey2) cytoplasm (Hey2)
Anatomy Link Frequency
cardiogenic 1
heart 1
Hey2 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 17 100.00 Very High Very High Very High
ischemia 12 100.00 Very High Very High Very High
cytokine 216 99.98 Very High Very High Very High
Inflammation 126 96.04 Very High Very High Very High
Calcium channel 4 92.96 High High
Inflammatory response 16 91.64 High High
Inflammatory mediators 17 87.56 High High
tolerance 1 82.12 Quite High
metalloproteinase 8 59.24 Quite High
fibrosis 5 54.68 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 254 100.00 Very High Very High Very High
Heart Failure 244 100.00 Very High Very High Very High
Cv Unclassified Under Development 34 100.00 Very High Very High Very High
Heart Rate Under Development 24 100.00 Very High Very High Very High
Cv General 3 Under Development 18 100.00 Very High Very High Very High
Cv General 2 Under Development 3 99.76 Very High Very High Very High
Appetite Loss 90 99.62 Very High Very High Very High
Cardiovascular Disorder Under Development 75 96.80 Very High Very High Very High
Arrhythmia Under Development 9 96.76 Very High Very High Very High
Acute Myocarditis 2 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antimetabolite agents, such as capecitabine or cytarabine, can induce ischemia, pericarditis, CHF, and cardiogenic shock.
Positive_regulation (induce) of CHF in cardiogenic associated with heart rate under development, cv general 2 under development, ischemia and cva
1) Confidence 0.05 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2802286 Disease Relevance 2.10 Pain Relevance 0.17
Moreover, in a recent report from a large population of CHF patients (the cytokine database from the Vesnarinone Trial [VEST]) [40,41], circulating levels of inflammatory cytokines (TNF-?
Positive_regulation (population) of CHF associated with inflammation, heart failure and cytokine
2) Confidence 0.04 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC64832 Disease Relevance 1.15 Pain Relevance 0.44
There are few data on how traditional cardiovascular medications influence the persistent immune activation that occurs in CHF.
Positive_regulation (occurs) of CHF associated with heart failure
3) Confidence 0.03 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC64832 Disease Relevance 0.83 Pain Relevance 0.37
The persistent immune activation in CHF has been reported to occur independently of the aetiology of heart failure [11,18], possibly representing a final common pathogenic pathway in this disorder.
Positive_regulation (activation) of CHF in heart associated with heart failure
4) Confidence 0.03 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC64832 Disease Relevance 1.35 Pain Relevance 0.40
Accordingly, persistent stimulation by microbial antigens might well lead to cytokine activation in CHF patients (Fig. 1).
Positive_regulation (activation) of CHF associated with heart failure and cytokine
5) Confidence 0.03 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC64832 Disease Relevance 1.75 Pain Relevance 0.41
in a murine model of MI-induced CHF has also been reported by another group (Schulze et al. 2003), raising the intriguing possibility that this may be representative of a species-specific difference between humans and rodents in the peripheral inflammatory response to CHF.
Positive_regulation (induced) of CHF associated with inflammatory response and myocardial infarction
6) Confidence 0.02 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.96 Pain Relevance 0.12
AGRP administration for 2 weeks to reverse cardiac cachexia in a rat model of CHF induced by aortic banding.
Positive_regulation (induced) of CHF associated with appetite loss and myocardial infarction
7) Confidence 0.02 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.12 Pain Relevance 0
However, data from the recently published meta-analyses indicate that treatment with TZDs significantly increase the risk of CHF (RR 1.72; P = .002) [101].
Positive_regulation (increase) of CHF associated with heart rate under development
8) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 0.85 Pain Relevance 0.04

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