INT171091

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Context Info
Confidence 0.16
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.27
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
skin 1
P-1 1
SLC10A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 405 99.46 Very High Very High Very High
Inflammation 67 75.00 Quite High
Osteoarthritis 15 75.00 Quite High
Potency 3 63.76 Quite High
spinal inflammation 25 55.08 Quite High
methotrexate 30 5.00 Very Low Very Low Very Low
Arthritis 25 5.00 Very Low Very Low Very Low
cytokine 19 5.00 Very Low Very Low Very Low
Rheumatism 10 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 430 99.46 Very High Very High Very High
Anovulation 1 99.24 Very High Very High Very High
Chromosome Aberrations 230 99.20 Very High Very High Very High
Reprotox - General 3 5 98.60 Very High Very High Very High
Disease 42 97.84 Very High Very High Very High
Monosomy 55 95.28 Very High Very High Very High
Spondylarthropathies 45 94.80 High High
Generaliased Trisomy 75 89.68 High High
Injury 101 89.32 High High
Cancer 48 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, greater accumulation of P4 can contribute to anovulation and infertility in women with 21-OHD.
Positive_regulation (accumulation) of P4 associated with reprotox - general 3 and anovulation
1) Confidence 0.16 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.58 Pain Relevance 0.03
Measurement of P4 and estradiol (E2) levels
Positive_regulation (Measurement) of P4
2) Confidence 0.12 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0 Pain Relevance 0
In P1, P2, P3 and P4, an increase in the frequency of IFN-?
Positive_regulation (increase) of P4
3) Confidence 0.08 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.28 Pain Relevance 0
As in RA, the percentage of +7 SFB increased until P-4, and the percentage of SFB monosomic for chromosome 18 was always higher than the percentage of SFB polysomic for chromosome 18 (Fig. 2).
Positive_regulation (increased) of P-4 associated with rheumatoid arthritis
4) Confidence 0.02 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64845 Disease Relevance 0.75 Pain Relevance 0.12
The mean percentages of SFB polysomic for chromosomes 4, 6, 7, and 9 equally increased until P-4, leading to levels above threshold for these chromosomes in P-4 (Supplementary Fig. 1).
Positive_regulation (increased) of P-4
5) Confidence 0.02 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64845 Disease Relevance 1.21 Pain Relevance 0.14
The percentage of polysomies was increased in P-4.
Positive_regulation (increased) of P-4
6) Confidence 0.01 Published 2001 Journal Arthritis Res Section Abstract Doc Link PMC64845 Disease Relevance 1.64 Pain Relevance 0.21
Until P-4, the percentage of skin FB showing chromosome gains or losses increased (Supplementary Table 6).
Positive_regulation (increased) of P-4 in skin
7) Confidence 0.01 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64845 Disease Relevance 1.21 Pain Relevance 0.38
The percentage of +7 SFB increased between P-1 and P-4, indicating a selective growth advantage for 7-polysomic SFB in vitro (Fig. 1).
Positive_regulation (increased) of P-4 in P-1
8) Confidence 0.01 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64845 Disease Relevance 0.60 Pain Relevance 0.11

General Comments

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