INT171092

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Context Info
Confidence 0.05
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.57
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MCF2) cytoskeleton (MCF2) cytoplasm (MCF2)
Anatomy Link Frequency
MCF-7 13
heart 2
MDA-MB-231 1
MCF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 81 72.24 Quite High
Inflammation 11 50.00 Quite Low
Osteoarthritis 3 50.00 Quite Low
imagery 5 42.60 Quite Low
Pain 3 20.00 Low Low
cytokine 3 18.80 Low Low
alcohol 1 13.40 Low Low
methotrexate 6 8.32 Low Low
agonist 14 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 240 100.00 Very High Very High Very High
Down Syndrome 1 97.56 Very High Very High Very High
Generaliased Trisomy 15 95.08 Very High Very High Very High
Chromosome Aberrations 46 85.12 High High
Apoptosis 96 83.92 Quite High
Cancer 89 78.56 Quite High
Rheumatoid Arthritis 86 72.24 Quite High
Disease 15 60.48 Quite High
Colon Cancer 30 58.88 Quite High
Sarcoma 2 50.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, lack of overexpression of the proto-oncogene ets-2, encoded on chromosome 21, in heart tissue of patients with Down syndrome provides evidence against a gene-dosage effect of polysomies [40].
Positive_regulation (overexpression) of Gene_expression (overexpression) of proto-oncogene ets-2 in heart associated with down syndrome
1) Confidence 0.05 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64845 Disease Relevance 0.67 Pain Relevance 0.10
The ER-positive aromatase-overexpressing human breast cancer MCF-7 cell line, MCF-7aro, prepared by stable transfection with the human placental aromatase gene and Geneticin selection [32], was kindly provided by Dr.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of MCF-7aro in MCF-7 associated with breast cancer
2) Confidence 0.04 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2515307 Disease Relevance 0.10 Pain Relevance 0
Itoh et al. [89] also found differences between letrozole, anastrozole, and tamoxifen using microarray analysis on MCF-7 cells stably transfected with the aromatase gene (MCF-7Aro).
Positive_regulation (transfected) of Gene_expression (transfected) of MCF-7 in MCF-7
3) Confidence 0.04 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.26 Pain Relevance 0
MCF-7 cells were transfected as previously described [26] using 2 ?
Positive_regulation (transfected) of Gene_expression (transfected) of MCF-7 in MCF-7
4) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.06 Pain Relevance 0
Stable transfection of MCF-7 cells with the full-length ACSL4 cDNA under the control of a tetracycline response element resulted in increased COX-2 constitutive expression.
Positive_regulation (transfection) of Gene_expression (transfection) of MCF-7 in MCF-7
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.06 Pain Relevance 0
For transient transfection of MDA-MB-231 and MCF-7, cells were seeded the day before and grown up to 80% confluence.
Positive_regulation (transfection) of Gene_expression (transfection) of MCF-7 in MCF-7
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0 Pain Relevance 0
MCF-7 cells (expressing high levels of ER?)
Positive_regulation (levels) of Gene_expression (expressing) of MCF-7 in MCF-7
7) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.42 Pain Relevance 0
For transient transfection of MDA-MB-231 and MCF-7, cells were seeded the day before and grown up to 80% confluence.
Positive_regulation (transfection) of in MDA-MB-231 Gene_expression (transfection) of MCF-7 in MCF-7
8) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0 Pain Relevance 0

General Comments

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