INT171096

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.42
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFA) extracellular region (PDGFA) embryo development (PDGFA)
cell-cell signaling (PDGFA)
Anatomy Link Frequency
platelet 3
blood 1
hepatocyte 1
PDGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 98.96 Very High Very High Very High
rheumatoid arthritis 81 90.20 High High
anesthesia 6 87.92 High High
epidural 1 87.48 High High
Inflammatory response 6 82.04 Quite High
addiction 12 71.52 Quite High
Inflammation 24 50.00 Quite Low
Osteoarthritis 3 50.00 Quite Low
imagery 7 30.48 Quite Low
pain flank 1 25.28 Quite Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 6 99.38 Very High Very High Very High
Hypoxia 9 98.74 Very High Very High Very High
Renal Cell Carcinoma 58 98.08 Very High Very High Very High
Hematoma 1 96.76 Very High Very High Very High
Rheumatic Diseases 10 93.88 High High
Coagulation Disorder 1 93.16 High High
Cancer 56 92.28 High High
Rheumatoid Arthritis 86 90.20 High High
Chromosome Aberrations 46 89.04 High High
Renal Cancer 38 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Transcription (levels) of PDGFA
1) Confidence 0.47 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.37 Pain Relevance 0.49
and results in the transcription of genes that regulate angiogenesis such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF?).
Transcription (transcription) of PDGF in platelet
2) Confidence 0.33 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.93 Pain Relevance 0
and results in the transcription of genes that regulate angiogenesis such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF?).
Transcription (transcription) of platelet-derived growth factor in platelet
3) Confidence 0.33 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.93 Pain Relevance 0
This hemostatic plug prevents further blood loss and provides a medium for the activity of various growth factors including platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-?)
Transcription (activity) of PDGF in blood associated with pressure volume 2 under development
4) Confidence 0.10 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.45 Pain Relevance 0.04
Without VHL, in the presence of uninhibited hypoxia-inducible factor, the cascade of intranuclear events leads to transcription of a number of genes, including vascular endothelium growth factor (VEGF) and platelet-derived growth factor (PDGF), leading to increased growth and vascular angiogenesis.8
Transcription (transcription) of PDGF in platelet associated with hypoxia
5) Confidence 0.04 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886329 Disease Relevance 1.02 Pain Relevance 0
These include cytokines/ growth factors and their receptors (e.g. platelet-derived growth factor-alpha chain, IL-6, epidermal growth factor, insulin-like growth factor, hepatocyte growth factor and its receptor); transcription factors (e.g.
Transcription (derived) of growth factor-alpha chain in hepatocyte associated with cytokine
6) Confidence 0.03 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64845 Disease Relevance 0.73 Pain Relevance 0.26

General Comments

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