INT171099

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.65
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Rrad (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 25 89.36 High High
Calcium channel 1 80.32 Quite High
spinal inflammation 13 45.52 Quite Low
Glutamate 1 40.68 Quite Low
Hippocampus 1 15.60 Low Low
Inflammation 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Enkephalin 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 35 100.00 Very High Very High Very High
Hypogonadotropic Hypogonadism 34 97.70 Very High Very High Very High
Rheumatoid Arthritis 25 89.36 High High
Systemic Lupus Erythematosus 15 89.04 High High
Syndrome 13 87.52 High High
Dermatomyositis 7 71.28 Quite High
Apoptosis 4 48.40 Quite Low
Low Back Pain 13 45.52 Quite Low
Disease 2 18.08 Low Low
Shock 1 17.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, given what is known about the role of Rrad in other systems, increased Rrad protein would also serve to downregulate the response of SCN cells to subsequent stimulation.
Positive_regulation (increased) of Rrad
1) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0.04
Because the group of patients we studied was so heterogeneous (hypogonadism due to various causes, and various RAD), we can conclude only that the hypogonadism itself (regardless of its particular etiology) and the very low serum testosterone levels are associated with the increased frequency of RAD.
Positive_regulation (increased) of RAD associated with autoimmune disease and hypogonadotropic hypogonadism
2) Confidence 0.14 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64847 Disease Relevance 1.65 Pain Relevance 0.19

General Comments

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