INT171105

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.02
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
Anatomy Link Frequency
osteoblasts 2
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 25 95.40 Very High Very High Very High
endometriosis 7 94.64 High High
cINOD 68 77.24 Quite High
aspirin 31 66.60 Quite High
carbamazepine 17 57.12 Quite High
Inflammation 11 50.00 Quite Low
antiepileptic Drug 1 50.00 Quite Low
spinal inflammation 13 27.08 Quite Low
antagonist 44 5.00 Very Low Very Low Very Low
agonist 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 112 99.84 Very High Very High Very High
Reprotox - General 3 38 98.84 Very High Very High Very High
Cancer 85 98.82 Very High Very High Very High
Rheumatoid Arthritis 25 95.40 Very High Very High Very High
Apoptosis 7 94.96 High High
Endometriosis (extended) 16 94.64 High High
Ovarian Hyperstimulation Syndrome 11 93.92 High High
Autoimmune Disease 35 91.72 High High
Targeted Disruption 17 89.92 High High
Syndrome 15 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition the use of aromatase inhibitors to improve the outcome of treatment after assisted reproduction as discussed earlier in this review is an exciting area of application.



1.3 Use of aromatase inhibitors to improve treatment outcome after ovarian stimulation and assisted reproduction

Positive_regulation (improve) of Positive_regulation (use) of aromatase
1) Confidence 0.39 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.61 Pain Relevance 0.05
Vitamin D3 is an important regulator of aromatase activity and physiological concentrations of vitamin D3 are necessary for maintenance of aromatase activity in osteoblasts [59].
Positive_regulation (necessary) of Positive_regulation (maintenance) of aromatase in osteoblasts
2) Confidence 0.12 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.19 Pain Relevance 0.03
In breast cancer PGs, particularly PGE2, have an organ-site-specific effect of increasing the levels of aromatase, thereby increasing estrogen and progesterone synthesis [10-12].
Positive_regulation (increasing) of Positive_regulation (increasing) of aromatase associated with breast cancer
3) Confidence 0.10 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797023 Disease Relevance 1.17 Pain Relevance 0.32
An increase in the activity of aromatase induced locally could explain the drop in androgen levels and the increase in estrogens observed in patients with RA [38].
Positive_regulation (increase) of Positive_regulation (increase) of aromatase associated with rheumatoid arthritis
4) Confidence 0.08 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64847 Disease Relevance 1.20 Pain Relevance 0.18
Thus, both paracrine (tumor cell derived) and autocrine (stromally produced) PGE2 may contribute to aromatase upregulation in breast cancers.
Spec (may) Positive_regulation (contribute) of Positive_regulation (upregulation) of aromatase associated with cancer and breast cancer
5) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.85 Pain Relevance 0

General Comments

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