INT171112

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Context Info
Confidence 0.15
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.37
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Spg7) mitochondrion (Spg7) cell adhesion (Spg7)
mitochondrion organization (Spg7)
Spg7 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 5 98.12 Very High Very High Very High
Arthritis 50 97.64 Very High Very High Very High
cytokine 33 97.56 Very High Very High Very High
Inflammation 40 97.20 Very High Very High Very High
Inflammatory response 9 85.56 High High
agonist 1 84.88 Quite High
rheumatoid arthritis 3 67.16 Quite High
Central nervous system 18 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infectious Arthritis 10 97.64 Very High Very High Very High
INFLAMMATION 43 97.20 Very High Very High Very High
Arthritis 46 82.16 Quite High
Disease 9 78.32 Quite High
Drug Induced Neurotoxicity 1 75.84 Quite High
Rheumatoid Arthritis 3 67.16 Quite High
Seronegative Spondarthritis 1 66.16 Quite High
Cancer 3 54.16 Quite High
Necrosis 3 53.60 Quite High
Injury 6 46.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One potential effect of such irrigation would be to decrease the local levels of PGN.
Negative_regulation (decrease) of PGN
1) Confidence 0.15 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64849 Disease Relevance 1.06 Pain Relevance 0.40
Those authors found that the effect of PGN was critically dependent on TLR2, as TLR2-deficient mice demonstrated reduced cytokine and chemokine production after PGN challenge [34].
Negative_regulation (effect) of PGN associated with chemokine and cytokine
2) Confidence 0.05 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.31 Pain Relevance 0.39

General Comments

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