INT171117

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 14.87
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgam) nucleus (Itgam)
Anatomy Link Frequency
microglia 5
neutrophil 4
macrophages 3
endothelial cells 3
granulocytes 2
Itgam (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 605 99.84 Very High Very High Very High
psoriasis 48 99.68 Very High Very High Very High
cytokine 422 98.96 Very High Very High Very High
Inflammatory response 66 98.48 Very High Very High Very High
Arthritis 65 92.60 High High
Multiple sclerosis 14 91.64 High High
agonist 38 91.08 High High
ischemia 46 86.96 High High
Nerve growth factor 3 81.68 Quite High
antagonist 22 81.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 684 99.84 Very High Very High Very High
Psoriasis 57 99.68 Very High Very High Very High
Disease 396 99.40 Very High Very High Very High
Infection 262 99.16 Very High Very High Very High
Urological Neuroanatomy 22 97.82 Very High Very High Very High
Adhesions 131 96.40 Very High Very High Very High
Arthritis 57 96.08 Very High Very High Very High
Demyelinating Disease 14 95.76 Very High Very High Very High
Polyps 40 94.96 High High
Multiple Sclerosis 120 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Control muscle did not show a significant immunoreactivity for MMP-9, CD11b and MHCd (Fig. 3B,C and 3D, respectively), and revealed a normal immunoreactivity of perlecan and laminin B2 (Fig. 3E and 3F, respectively).
CD11b Neg (not) Binding (immunoreactivity) of in muscle
1) Confidence 0.36 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1929071 Disease Relevance 0.08 Pain Relevance 0.08
The presence of circulating MPO can be directly linked to the pathology of P. gingivalis infection in wild-type mice, since this protein by binding to CD11b/CD18 integrins serves as a powerful autocrine and paracrine stimulator of neutrophil activation, provoking degranulation, expression of integrins, and oxidative burst discharge [48].
CD11b/CD18 Binding (binding) of in neutrophil associated with urological neuroanatomy and infection
2) Confidence 0.35 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1522038 Disease Relevance 0.78 Pain Relevance 0
Immunoreactivity for CD11b and GFAP, markers for activated microglia and astrocyte, respectively, increased in 13–15 month-old TLR4m AD mice compared to TLR4w AD mice.
CD11b Binding (Immunoreactivity) of in microglia associated with disease
3) Confidence 0.26 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.15 Pain Relevance 0.10
Remarkebly, activated microglial and astrocytic cells were colocalized as demonstrated by double staining for CD11b and GFAP, already in the brain of young APP [V717I] mice, suggesting the formation of inflammatory foci in both brain regions evaluated (not shown).
CD11b Binding (staining) of in brain associated with inflammation
4) Confidence 0.25 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1274341 Disease Relevance 0.76 Pain Relevance 0.26
Less intense CD11b staining and reduced amounts of MIP1?
CD11b Binding (intense) of
5) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396504 Disease Relevance 0.73 Pain Relevance 0.09
The following primary antibodies were used as cell-markers: monoclonal anti-NeuN for neurons (1:2,000; Chemicon, Hampshire, UK); polyclonal rabbit anti-GFAP for astrocytes (1:100; Shandon Immunon, Pittsburgh, PA) and monoclonal rat anti-CD11b for microglia and monocytes/macrophages (1:100; Accurate Chemical, Westbury, NY).
CD11b Binding (microglia) of in microglia
6) Confidence 0.24 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1867808 Disease Relevance 0.15 Pain Relevance 0
showed increased protein expression by CD11b+CD45dim microglia and infiltrating CD11b+CD45high macrophages/granulocytes after 24 hours of pMCAO (Figure 5E).
CD11b Binding (microglia) of in microglia
7) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.07 Pain Relevance 0
Furthermore, numbers of CD11b+CD45high macrophages/granulocytes recruited to ischemic cortex 24 hours after pMCAO were not different between BM-chimeric mice and non-irradiated mice.
CD11b Binding (recruited) of in granulocytes
8) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.09 Pain Relevance 0.04
-expressing CD11b+CD45dim microglia and infiltrating CD11b+CD45high macrophages/granulocytes peaked between 12 and 24 hours after pMCAO (Figure 5C).
CD11b Binding (microglia) of in granulocytes
9) Confidence 0.22 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.05 Pain Relevance 0
Immunofluorescence staining revealed overlap of both CD11b (AlexaFluor 488) and Gr1 (AlexaFluor 594) with ProSense-680 signal (Fig. 4a–e), in cells that were dispersed through out the polyp stroma.
CD11b Binding (overlap) of in stroma associated with polyps
10) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.47 Pain Relevance 0
Experiment 2: A single and repeated central cytokine infusion differentially influence hippocampal cell proliferation (BrdU, CD11b)
CD11b Binding (proliferation) of associated with cytokine
11) Confidence 0.19 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695223 Disease Relevance 0.18 Pain Relevance 0.20
This indicates that rh-IL-10 enhances CR3 expression so that the bacteria enter through CR3 for efficient destruction by phagocytes.


CR3 Binding (enter) of in phagocytes
12) Confidence 0.17 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.48 Pain Relevance 0
m caudal relative to the sections evaluated for Mac-1 immunoreactivity (Fig. 3 or Fig. 4) and 30 ?
Mac-1 Binding (immunoreactivity) of
13) Confidence 0.15 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.48 Pain Relevance 0
Importantly, we could demonstrate that PGD2 was operating directly on the neutrophils, because when these cells were harvested after migrating across a TNF-stimulated endothelial cells they had up-regulated CD11b (the alpha subunit of the ?
CD11b Binding (migrating) of in endothelial cells
14) Confidence 0.15 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0 Pain Relevance 0.09
Importantly, we could demonstrate that PGD2 was operating directly on the neutrophils, because when these cells were harvested after migrating across a TNF-stimulated endothelial cells they had up-regulated CD11b (the alpha subunit of the ?
CD11b Binding (endothelial cells) of in endothelial cells
15) Confidence 0.15 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0 Pain Relevance 0.08
2 integrin CD11b/CD18 that is required for efficient neutrophil transmigration) and proteolytically shed l-selectin (Figure 8).
CD11b Binding (integrin) of in neutrophil
16) Confidence 0.15 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0 Pain Relevance 0.08
or microglia based on staining for acid phosphatase or CD11b.
CD11b Binding (staining) of in microglia
17) Confidence 0.14 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.76 Pain Relevance 0.12
The majority of the lining cells in the nonproliferative synovial tissue was stained with Mac-1, recognizing resident macrophages.
Mac-1 Binding (recognizing) of in lining cells
18) Confidence 0.13 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64849 Disease Relevance 1.24 Pain Relevance 0.38
Cells stained with either CD11b, CD11c, or a combination of both cell markers, were found and confirmed to be DCs by their typical appearance characterized by cytoplasmic prolongations (Figure 7C, yellow arrows).
CD11b Binding (combination) of in DCs
19) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0 Pain Relevance 0
LFA-1, Mac-1, and p159,95, members of the ?
Mac-1 Binding (p159,95) of
20) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721316 Disease Relevance 0.58 Pain Relevance 0.30

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox