INT171133

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.42
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CD28) plasma membrane (CD28)
Anatomy Link Frequency
T cells 6
lymphocytes 1
CD28 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 204 99.76 Very High Very High Very High
Inflammation 93 94.48 High High
cytokine 63 90.80 High High
Arthritis 94 88.96 High High
Neuritis 2 76.32 Quite High
psoriasis 3 58.56 Quite High
chemokine 54 57.44 Quite High
rheumatoid arthritis 66 57.00 Quite High
spondylitis 16 55.96 Quite High
Infliximab 2 50.08 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 220 99.76 Very High Very High Very High
Cancer 18 97.80 Very High Very High Very High
Necrosis 15 97.52 Very High Very High Very High
Disease 91 94.80 High High
INFLAMMATION 93 94.48 High High
Juvenile Chronic Polyarthritis 40 88.96 High High
Benign Monoclonal Gammopathies 2 87.24 High High
Neuritis 2 76.32 Quite High
Colitis 3 75.36 Quite High
Graft Vs Host Disease 5 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD8+CD28- T cells have been reported to be effector cells, producing perforin, granzyme B, tumour necrosis factor-?
Localization (reported) of CD28 in T cells associated with necrosis and cancer
1) Confidence 0.71 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 1.29 Pain Relevance 0.42
Clinical relevance of CD4+CD28- T cells in ankylosing spondylitis
Localization (relevance) of CD28 in T cells associated with spinal inflammation
2) Confidence 0.62 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193730 Disease Relevance 0.85 Pain Relevance 0.43
For the isolation of CD4+CD28+ and CD4+CD28null T cells, the MACS® CD4+ T-cell multisort kit and magnetic bead labelled anti-phycoerythrin antibodies were applied according to the manufacturer's instructions (Miltenyi Biotech, Amsterdam, The Netherlands).
Localization (isolation) of CD28 in T-cell
3) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.05 Pain Relevance 0.03
For the isolation of CD4+CD28+ and CD4+CD28null T cells, the MACS® CD4+ T-cell multisort kit and magnetic bead labelled anti-phycoerythrin antibodies were applied according to the manufacturer's instructions (Miltenyi Biotech, Amsterdam, The Netherlands).
Localization (isolation) of CD28null in T-cell
4) Confidence 0.61 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.05 Pain Relevance 0.03
Cells were then stained for their surface antigens CD28 and CD8 and, after permeabilization, with FITC-conjugated anti-perforin, anti-IFN-?
Localization (permeabilization) of CD28
5) Confidence 0.31 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.35 Pain Relevance 0.18
However, a significant proportion of CCL5+ cells within the synovial fluid were still CD28+ and CD45RA- (Figure 5b), while in PB of both patients and controls, the majority of CD8+CCL5+ T cells were CD28-CD45RA+.
Localization (proportion) of CD28 in T cells
6) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.17 Pain Relevance 0.14
98 nM and inhibited anti-CD3/CD-28-induced secretion of IL-2 in T cells isolated from human peripheral blood lymphocytes with IC50?
Localization (secretion) of CD-28-induced in lymphocytes
7) Confidence 0.15 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.29 Pain Relevance 0.09
T cells for 96hrs with pbCD3/sCD28 in presence or absence of IL-4 or TGF-?
Localization (presence) of sCD28 in T cells
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.29 Pain Relevance 0.12
In addition, as compared to pbCD3/sCD28 plus TGF-?
Localization (sCD28) of sCD28
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806834 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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