INT171147

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 6.11
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Anatomy Link Frequency
nucleus 3
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 139 97.92 Very High Very High Very High
chemokine 13 94.56 High High
Spinal cord 25 91.16 High High
Inflammatory response 38 88.12 High High
cytokine 67 87.60 High High
allodynia 9 77.60 Quite High
peripheral neuropathy 2 75.68 Quite High
Spinal nerve ligature 13 72.56 Quite High
medulla 27 62.96 Quite High
Peripheral nerve injury 9 62.88 Quite High
Disease Link Frequency Relevance Heat
Stress 31 99.68 Very High Very High Very High
INFLAMMATION 190 97.92 Very High Very High Very High
Atherosclerosis 6 97.64 Very High Very High Very High
Toxicity 33 97.60 Very High Very High Very High
Alzheimer's Dementia 12 96.92 Very High Very High Very High
Vasculitis 6 93.12 High High
Frailty 8 91.44 High High
Myocardial Infarction 6 89.72 High High
Apoptosis 47 88.92 High High
Obstructive Jaundice 48 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B p65 is activated and binds to specific ?
p65 Binding (binds) of
1) Confidence 0.35 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2790077 Disease Relevance 1.36 Pain Relevance 0.14
B is involved in iNOS gene expression and is associated with the translocation of p50:p65 heterodimer into the nucleus.
p65 Binding (heterodimer) of in nucleus
2) Confidence 0.12 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.54 Pain Relevance 0.09
 : see [67]) cause dissociation of this complex, releasing p50-p65 that then translocates to the nucleus and binds to specific ?
p50-p65 Binding (binds) of in nucleus
3) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.29 Pain Relevance 0.04
B, a heterodimer consisting of 2 proteins, p50 and p65, passes into the nucleus, where it binds to kB sites in the promoter region of numerous genes involved in inflammation [29].
p65 Binding (heterodimer) of in nucleus associated with inflammation
4) Confidence 0.10 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.72 Pain Relevance 0.27
The antibody recognizes an epitope overlapping the nuclear location signal of p65 subunit and therefore selectively stains released activated NF-?
p65 Binding (recognizes) of
5) Confidence 0.10 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.91 Pain Relevance 0.12
B is bound to p50-p65, NF?
p50-p65 Binding (bound) of
6) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.32 Pain Relevance 0.04
B resides in the cytoplasm in an inactive form consisting of three subunits: p50 and p65 (constituting the factor dimer p50-p65) and the I?
p50-p65 Binding (dimer) of
7) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.32 Pain Relevance 0.05
B subunit p65, because in contrast to the p50 subunit, p65 contains the transcription activation domain.
p65 Binding (subunit) of
8) Confidence 0.09 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.93 Pain Relevance 0.13
-induced MnSOD activation resulted from an enhanced binding of the dimer p50-p65 to the promoter/enhancer regions of the MnSOD gene [23].
p50-p65 Binding (binding) of
9) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3004876 Disease Relevance 0.33 Pain Relevance 0.10
In most cell types, p65 associated with I?
p65 Binding (associated) of
10) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1361774 Disease Relevance 0.39 Pain Relevance 0.40

General Comments

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