INT171149

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Syt1) cytoplasm (Syt1)
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 14 50.00 Quite Low
Nerve growth factor 51 45.20 Quite Low
Neurotransmitter 15 42.80 Quite Low
chemokine 4 26.24 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 11 96.00 Very High Very High Very High
Adhesions 9 68.84 Quite High
Increased Venous Pressure Under Development 12 54.24 Quite High
INFLAMMATION 15 50.00 Quite Low
Neuroblastoma 9 39.64 Quite Low
Albuminuria 6 36.84 Quite Low
Coronary Heart Disease 6 34.12 Quite Low
Cancer 6 29.32 Quite Low
Stress 3 18.64 Low Low
Hypertension 8 16.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, it can be suggested that decreased expression of SytI in PC12 (WT-Akt) cells might be due to the Akt-mediated inhibition of the Raf-MAPK pathway.
Negative_regulation (decreased) of Gene_expression (expression) of SytI
1) Confidence 0.45 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0
pathway does not appear to be implicated in the decreased expression of SytI in PC12 (WT-Akt).
Negative_regulation (decreased) of Gene_expression (expression) of SytI
2) Confidence 0.33 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0
Effect of an Akt-specific inhibitor on expression of MafK, SytI, and Syn-1 genes in PC12 (WT-Akt) cells
Negative_regulation (inhibitor) of Gene_expression (expression) of SytI
3) Confidence 0.33 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.05 Pain Relevance 0
PDTC markedly reduced p65 expression (Fig. 22).
Negative_regulation (reduced) of Gene_expression (expression) of p65
4) Confidence 0.11 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.16 Pain Relevance 0

General Comments

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