INT171219

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.04
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plau) extracellular space (Plau) extracellular region (Plau)
kinase activity (Plau)
Anatomy Link Frequency
plasma 1
embryos 1
Plau (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 6 98.48 Very High Very High Very High
Kinase C 5 67.72 Quite High
cINOD 25 15.84 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
peptic ulcer disease 6 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 109 97.68 Very High Very High Very High
Stress 9 89.20 High High
Metastasis 42 72.80 Quite High
Cancer 154 60.88 Quite High
Adenoma 6 60.80 Quite High
Death 3 57.20 Quite High
Apoptosis 31 43.84 Quite Low
Hypertrophy 1 21.16 Low Low
Incontinence 6 14.80 Low Low
Dysgeusia 6 14.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes in uPA, PAI-1 and PGE2 were not significant at either dose for pre- or postmenopausal women.
Regulation (changes) of uPA
1) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0 Pain Relevance 0
Patients receiving celecoxib 200 mg bid demonstrated decreased uPA concentrations in NAF and plasma whereas patients receiving celecoxib 400 mg bid demonstrated increased concentrations of uPA in both NAF and plasma.
Regulation (concentrations) of uPA in plasma
2) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.37 Pain Relevance 0
We carried out experiments to investigate whether the COX-2 inhibitor celecoxib at a dose of either 200 mg bid or 400 mg bid could significantly affect endogenous uPA, PAI-1 or PGE2 production in women at increased risk for breast cancer.
Regulation (affect) of uPA associated with breast cancer and cox-2 inhibitor
3) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.17 Pain Relevance 0.05
We first evaluated the change in uPA, PAI-1 and PGE2 concentration in the NAF of each participant after low and high dose celecoxib administration (Table 2).
Regulation (change) of uPA
4) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0 Pain Relevance 0
The different uPA response was more noted in post- than in premenopausal women, in whom celecoxib concentrations tended to be higher.
Regulation (response) of uPA
5) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.29 Pain Relevance 0.03
The change in neither uPA nor PGE2 was significant for either pre- or postmenopausal women.


Neg (neither) Regulation (change) of uPA
6) Confidence 0.22 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0 Pain Relevance 0
We found no effect on GnRH neuronal distribution in uPA-treated embryos and no uPA immunoreactivity.
Neg (no) Regulation (immunoreactivity) of uPA in embryos
7) Confidence 0.08 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0 Pain Relevance 0
expression, up regulation of the U-PA promoter in PC3 cells, and PSA induced by IL-6 in LNCaP cells [73,85,86].
Regulation (regulation) of U-PA
8) Confidence 0.07 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.21 Pain Relevance 0.03
The concentrations of pro-u-PA, plasminogen and Spectrozyme UK were as 20 nM, 5 nM and 100 ?
Regulation (concentrations) of pro-u-PA
9) Confidence 0.00 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707035 Disease Relevance 0 Pain Relevance 0

General Comments

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