INT171221

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2004
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ecm1) extracellular space (Ecm1) extracellular region (Ecm1)
proteinaceous extracellular matrix (Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
Anatomy Link Frequency
neuronal 2
Ecm1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 98.10 Very High Very High Very High
metalloproteinase 10 56.56 Quite High
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 3 84.72 Quite High
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Reprotox - General 3 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that IL-11 is a secreted cytokine with autocrine and paracrine activity, a direct effect on ECM molecule transcription would be dependent on coincident expression patterns of the ECM molecules, IL-11 and its receptors.
Regulation (dependent) of Gene_expression (expression) of ECM associated with cytokine
1) Confidence 0.06 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0.10
Though we did not localize PAR expression in our model system, it remains a possibility that their activation or inhibition may modulate the ECM composition and thus GnRH neuronal migration.
Spec (may) Regulation (modulate) of Gene_expression (composition) of ECM in neuronal
2) Confidence 0.02 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0.08 Pain Relevance 0

General Comments

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