INT171251

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Context Info
Confidence 0.20
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 10.46
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (BMI1) nucleus (BMI1) cytoplasm (BMI1)
Anatomy Link Frequency
knee 2
chondrocytes 1
blood 1
joint 1
hip 1
BMI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 116 99.08 Very High Very High Very High
Osteoarthritis 627 98.86 Very High Very High Very High
alcohol 10 98.10 Very High Very High Very High
depression 3 88.00 High High
Inflammatory mediators 6 84.64 Quite High
medial meniscus tear 4 65.56 Quite High
imagery 36 57.68 Quite High
rheumatoid arthritis 28 50.48 Quite High
Inflammation 59 5.00 Very Low Very Low Very Low
cytokine 38 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 620 100.00 Very High Very High Very High
Cancer 78 99.80 Very High Very High Very High
Breast Cancer 2 99.36 Very High Very High Very High
Injury 28 99.14 Very High Very High Very High
Pain 112 99.08 Very High Very High Very High
Thinness 6 98.88 Very High Very High Very High
Osteoarthritis 499 98.86 Very High Very High Very High
Knee Osteoarthritis 38 98.46 Very High Very High Very High
Nicotine Addiction 10 97.86 Very High Very High Very High
Abdominal Obesity 10 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It might also be instructive to follow pain-free persons with RKOA (without a history of knee trauma) to observe possible associations between changes in BMI and the risk for knee pain.


Regulation (changes) of BMI in knee associated with pain, obesity, injury and osteoarthritis
1) Confidence 0.20 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 1.83 Pain Relevance 1.01
Similar BMI values were found for patients undergoing unilateral and bilateral hip replacement and revision surgery.
Regulation (values) of BMI in hip
2) Confidence 0.10 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.46 Pain Relevance 0.11
Previous studies found that INK4A/ARF locus and AKT/PKB pathway are two important cancer relevant target of Bmi-1 in gastric and breast cancers [8,10].
Regulation (target) of Bmi-1 associated with cancer and breast cancer
3) Confidence 0.09 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.03 Pain Relevance 0
INK4A/ARF tumor suppressor locus is one of the most important cancer relevant targets of Bmi-1.
Regulation (targets) of Bmi-1 associated with cancer
4) Confidence 0.09 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.82 Pain Relevance 0
This was increased significantly to 30% with the addition of age but was essentially unchanged by the addition of the smoking and alcohol terms, although again we retained these terms in our standard model against which to test the effect of the addition of the BMI and ln hsCRP terms.
Regulation (effect) of BMI associated with nicotine addiction, obesity and alcohol
5) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 0.67 Pain Relevance 0.08
The effect of leptin on gene expression was shown to be dependent on the BMI of patients from whom the cells were originating.
Regulation (dependent) of BMI associated with obesity
6) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.20 Pain Relevance 0.11
The effect of various leptin treatments was determined in human OA chondrocytes categorized in two groups according to the BMI value of the patients from whom they originated.
Regulation (value) of BMI in chondrocytes associated with obesity and osteoarthritis
7) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.56 Pain Relevance 0.05
Another study conducted by the same authors [22] examined the risk factors for symptomatic knee OA 15–22 years after meniscectomy, at which time they investigated the influence of age, sex, BMI, extent of meniscal resection, cartilage status, and knee load on the development of radiologically evident OA of the knee and joint symptoms after meniscal resection.
Spec (investigated) Regulation (influence) of BMI in joint associated with osteoarthritis
8) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.71 Pain Relevance 0.33
Therefore, the health-related consequences for Asia-Pacific individuals appear to be more intense at an absolute BMI value when compared to their European descendant counterparts.
Regulation (value) of BMI associated with obesity
9) Confidence 0.00 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 1.30 Pain Relevance 0
Increased BMI was a predictor for smaller changes in blood THM levels.
Regulation (changes) of BMI in blood associated with obesity
10) Confidence 0.00 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199304 Disease Relevance 0.17 Pain Relevance 0
Another study conducted by the same authors [22] examined the risk factors for symptomatic knee OA 15–22 years after meniscectomy, at which time they investigated the influence of age, sex, BMI, extent of meniscal resection, cartilage status, and knee load on the development of radiologically evident OA of the knee and joint symptoms after meniscal resection.
Spec (investigated) Regulation (influence) of BMI in knee associated with osteoarthritis
11) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.71 Pain Relevance 0.33

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