INT171252

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 26.98
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (BMI1) nucleus (BMI1) cytoplasm (BMI1)
Anatomy Link Frequency
cartilage 3
stem cell 2
knee 2
plasma 1
skin 1
BMI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 437 100.00 Very High Very High Very High
rheumatoid arthritis 13 99.92 Very High Very High Very High
Pain 241 97.04 Very High Very High Very High
alcohol 21 95.54 Very High Very High Very High
Inflammation 82 94.24 High High
imagery 30 73.36 Quite High
Inflammatory mediators 10 65.76 Quite High
palliative 11 62.00 Quite High
cytokine 16 46.36 Quite Low
metalloproteinase 10 23.44 Low Low
Disease Link Frequency Relevance Heat
Obesity 1071 100.00 Very High Very High Very High
Cancer 427 100.00 Very High Very High Very High
Frailty 134 100.00 Very High Very High Very High
Rheumatoid Arthritis 13 99.92 Very High Very High Very High
Stomach Cancer 216 99.84 Very High Very High Very High
Cardiovascular Disease 103 99.70 Very High Very High Very High
Disorder Of Lipid Metabolism 57 99.66 Very High Very High Very High
Osteoarthritis 177 98.44 Very High Very High Very High
Overweight 99 98.40 Very High Very High Very High
Nasopharynx Cancer 145 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, qRT-PCR performed on the CTIP2 mutant mice skin, using mouse specific Bmi1 primers, showed significant down regulation of Bmi1 expression, suggesting a possible regulation of Bmi1 gene by Ctip2 (Fig.
Gene_expression (expression) of Bmi1 in skin
1) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.69 Pain Relevance 0
Nuclear co-localization of CTIP2 protein and cancer stem cell (CSC) marker BMI1 was observed in most, if not all of the cells expressing BMI1 in moderately and poorly differentiated tumors.


Gene_expression (expressing) of BMI1 in stem cell associated with cancer
2) Confidence 0.55 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2671404 Disease Relevance 0.83 Pain Relevance 0
A regression model was run for each BMI group.
Gene_expression (group) of BMI associated with obesity
3) Confidence 0.51 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.32 Pain Relevance 0.76
Similarly, Felson and colleagues [15] found that study subjects with symptomatic knee OA presented with elevated BMI levels compared to their asymptomatic counterparts.
Gene_expression (presented) of BMI in knee associated with obesity and osteoarthritis
4) Confidence 0.51 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.36 Pain Relevance 1.31
With BMI as the exposure factor, subjects with normal BMI (18.5 to 24.9 kg/m2) served as the reference group for the analyses (e.g.
Spec (analyses) Gene_expression (subjects) of BMI associated with obesity
5) Confidence 0.51 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.55 Pain Relevance 0.74
We therefore performed immunoflourescent co-staining for CTIP2 and BMI1 protein, in well, moderately and poorly differentiated HNSCC samples to see if some of the CTIP2 expressing cells also express the cancer stem cell (CSC) marker BMI1, previously implicated in self renewal and tumorigenesis [30], [31], [32], [33], [34], [35], [36], [37].
Gene_expression (express) of BMI1 in stem cell associated with cancer
6) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.84 Pain Relevance 0
BMI distributions
Gene_expression (distributions) of BMI
7) Confidence 0.26 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 0.83 Pain Relevance 0.03
Recently we reported that Bmi-1 was overexpressed in gastric cancer cell lines and gastric tumors and plays an important role in the carcinogenesis and progression of gastric cancer [10].
Gene_expression (overexpressed) of Bmi-1 associated with cancer and stomach cancer
8) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.67 Pain Relevance 0
Overexpression of Bmi-1 has been shown to immortalize and transform normal human cells via inhibiting cellular senescence, which constitutes a powerful barrier to oncogenesis [8,11].
Gene_expression (Overexpression) of Bmi-1 associated with aging
9) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.77 Pain Relevance 0
Our previous study showed that Bmi-1 was an independent negative prognosis factor and patients with high Bmi-1 expression survived significantly shorter than those with low and no Bmi-1 expression [10].
Gene_expression (expression) of Bmi-1
10) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 1.03 Pain Relevance 0
Our previous study showed that Bmi-1 was an independent negative prognosis factor and patients with high Bmi-1 expression survived significantly shorter than those with low and no Bmi-1 expression [10].
Neg (no) Gene_expression (expression) of Bmi-1
11) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2933612 Disease Relevance 0.95 Pain Relevance 0
For the multivariate model with log MTPM at 1 year using the same 4 factors, only PC1 of the knee adduction moment and BMI remained significant in the model (implant group: p = 0.1; BMI: p = 0.04; PC1 knee adduction moment: p = 0.09; PC1 knee flexion moment: p = 0.33).
Gene_expression (significant) of BMI in knee
12) Confidence 0.18 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0 Pain Relevance 0
It has been reported that high Bmi-1 oncoprotein expression was found to be positively correlated with poor prognosis of NPC patients.
Gene_expression (expression) of Bmi-1 associated with nasopharynx cancer
13) Confidence 0.12 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.50 Pain Relevance 0
BMI = body mass index; CRP = C-reactive protein; CV = coefficient of variation; hsCRP = high sensitivity CRP; IL = interleukin; ln = natural log; OA = osteoarthritis; RA = rheumatoid arthritis; SD = standard deviation; TNF?
Gene_expression (osteoarthritis) of BMI in body associated with obesity, rheumatoid arthritis and osteoarthritis
14) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 1.50 Pain Relevance 0.55
The further addition of smoking and alcohol to this model did not significantly increase the proportion of variation in total tibial cartilage volume explained, however we retained these variables in the analysis to form our standard model against which to test the addition of both BMI and ln hsCRP.
Gene_expression (addition) of BMI in cartilage associated with nicotine addiction, obesity and alcohol
15) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 0.50 Pain Relevance 0.07
In men, the BMI that produced the maximum HRQoL was 26.0, and in women it was 24.4.
Gene_expression (produced) of BMI associated with obesity
16) Confidence 0.07 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2788145 Disease Relevance 1.89 Pain Relevance 0.14
In the analysis of CVD outcome, LAP, BMI, WHpR, and WHtR were assessed using Cox proportional hazards regression analyses.
Gene_expression (assessed) of BMI associated with cardiovascular disease and obesity
17) Confidence 0.04 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2949857 Disease Relevance 1.19 Pain Relevance 0
It is worth noting that the BMI-dependent effect of leptin found for genes involved in matrix remodeling was not showed for COX-2, iNOS or IL-1 suggesting that the adipokine did not modulate the production of proinflammatory mediators in cartilage from obese patients.
Gene_expression (found) of BMI in cartilage associated with obesity
18) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.28 Pain Relevance 0.25
Consequently, leptin may protect cartilage from the degenerative process in patients with BMI of more than 30 kg/m2 through overexpression of genes encoding IGF-1, type 2 collagen and TIMP-2.
Gene_expression (overexpression) of BMI in cartilage associated with obesity
19) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.36 Pain Relevance 0.17
The Spearman's rho correlation method was used to evaluate the relation between gene expression and the BMI.
Gene_expression (expression) of BMI associated with obesity
20) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.39 Pain Relevance 0.04

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