INT171253

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Context Info
Confidence 0.53
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 39.41
Pain Relevance 11.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (BMI1) nucleus (BMI1) cytoplasm (BMI1)
Anatomy Link Frequency
knee 7
hip 5
joint 1
blood 1
lung 1
BMI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 569 99.98 Very High Very High Very High
rheumatoid arthritis 30 99.78 Very High Very High Very High
Osteoarthritis 973 99.68 Very High Very High Very High
Inflammatory marker 2 88.48 High High
Bile 9 81.60 Quite High
Inflammation 82 79.44 Quite High
palliative 7 75.36 Quite High
imagery 25 64.88 Quite High
Arthritis 35 64.40 Quite High
alcohol 10 58.44 Quite High
Disease Link Frequency Relevance Heat
Obesity 2003 100.00 Very High Very High Very High
Pain 554 99.98 Very High Very High Very High
Rheumatoid Arthritis 30 99.78 Very High Very High Very High
Gallstones 27 99.74 Very High Very High Very High
Frailty 208 99.68 Very High Very High Very High
Hip Osteoarthritis 225 99.54 Very High Very High Very High
Knee Osteoarthritis 227 99.46 Very High Very High Very High
Diabetes Mellitus 123 98.52 Very High Very High Very High
Overweight 316 97.96 Very High Very High Very High
Anxiety Disorder 12 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One such explanation may be that knee pain precedes a high BMI.
Positive_regulation (precedes) of BMI in knee associated with pain and obesity
1) Confidence 0.53 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.96 Pain Relevance 1.15
Similarly, Felson and colleagues [15] found that study subjects with symptomatic knee OA presented with elevated BMI levels compared to their asymptomatic counterparts.
Positive_regulation (elevated) of BMI in knee associated with obesity and osteoarthritis
2) Confidence 0.53 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.35 Pain Relevance 1.30
While our results demonstrate a strong link between increased BMI and knee pain among persons with RKOA, indicating overweight and obesity as a potential cause of knee pain, the cross-sectional design limits our ability to rule out alternative explanations.
Positive_regulation (increased) of BMI in knee associated with pain, obesity, osteoarthritis and overweight
3) Confidence 0.53 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.92 Pain Relevance 1.02
Although this would suggest that elevated BMI is a potential risk factor for knee pain among persons with RKOA, relatively little research has been conducted in this area.
Positive_regulation (elevated) of BMI in knee associated with pain, obesity and osteoarthritis
4) Confidence 0.53 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2651875 Disease Relevance 2.19 Pain Relevance 1.24
Unadjusted and adjusted odds ratios demonstrated a positive association between BMI group and pain for each successive elevated BMI category.
Positive_regulation (elevated) of BMI associated with pain and obesity
5) Confidence 0.35 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2651875 Disease Relevance 2.93 Pain Relevance 1.33
Elevated BMI was the risk factor, and knee pain status was the outcome factor.


Positive_regulation (Elevated) of BMI in knee associated with pain and obesity
6) Confidence 0.35 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2651875 Disease Relevance 2.81 Pain Relevance 1.40
Among subjects with RKOA, those presenting with an elevated BMI had a greater likelihood of knee pain compared to subjects with a normal BMI, and this chance rose with each successive elevated BMI category.
Positive_regulation (elevated) of BMI in knee associated with pain, obesity and osteoarthritis
7) Confidence 0.35 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2651875 Disease Relevance 2.82 Pain Relevance 1.24
Moreover, we cannot determine whether a subsequently increased BMI is more important than other factors in increasing the risk of hip OA.
Spec (whether) Positive_regulation (increased) of BMI in hip associated with osteoarthritis
8) Confidence 0.27 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.16 Pain Relevance 0.40
The patients with hip OA in our study also had higher BMIs than those of 55 hospitalized patients with hip fracture, 25 patients without any symptomatic hip problem who had an average BMI of 23, 25 patients without any symptomatic hip problem who had an average BMI of 24, or 30 patients with rheumatoid arthritis who had a mean BMI of 26.4.


Positive_regulation (average) of BMI in hip associated with frailty, rheumatoid arthritis and osteoarthritis
9) Confidence 0.19 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.29 Pain Relevance 0.13
The patients with hip OA in our study also had higher BMIs than those of 55 hospitalized patients with hip fracture, 25 patients without any symptomatic hip problem who had an average BMI of 23, 25 patients without any symptomatic hip problem who had an average BMI of 24, or 30 patients with rheumatoid arthritis who had a mean BMI of 26.4.


Positive_regulation (mean) of BMI in hip associated with frailty, rheumatoid arthritis and osteoarthritis
10) Confidence 0.19 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.41 Pain Relevance 0.13
The patients with hip OA in our study also had higher BMIs than those of 55 hospitalized patients with hip fracture, 25 patients without any symptomatic hip problem who had an average BMI of 23, 25 patients without any symptomatic hip problem who had an average BMI of 24, or 30 patients with rheumatoid arthritis who had a mean BMI of 26.4.


Positive_regulation (average) of BMI in hip associated with frailty, rheumatoid arthritis and osteoarthritis
11) Confidence 0.19 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.35 Pain Relevance 0.13
In our study, the combination of increased BMI and altered joint loading during gait preoperatively was associated with postoperative implant migration, which supports the notion that BMI is an important factor in patient triage and implant selection.
Positive_regulation (increased) of BMI in joint
12) Confidence 0.19 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2917572 Disease Relevance 0.99 Pain Relevance 0.14
Although not without limitations, our data provide additional support for the view that symptomatic unilateral and bilateral hip OA is associated with an increased BMI, especially between the ages of 30 and 59 years.
Positive_regulation (increased) of BMI in hip associated with osteoarthritis
13) Confidence 0.18 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83842 Disease Relevance 1.01 Pain Relevance 0.22
In both men and women, increased BMI had the biggest impact on mobility (in terms of the increase in the proportion of overweight or obese individuals stating it was a problem).
Positive_regulation (increased) of BMI associated with obesity and overweight
14) Confidence 0.08 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2788145 Disease Relevance 1.37 Pain Relevance 0
Nearly all aspects of HRQoL are adversely affected by elevated BMI.



Positive_regulation (elevated) of BMI associated with obesity
15) Confidence 0.05 Published 2009 Journal Qual Life Res Section Abstract Doc Link PMC2788145 Disease Relevance 1.17 Pain Relevance 0
Although BMI is a major determinant of CRP [21], our analysis indicates that the impact of hsCRP is not purely mediated through BMI.
Neg (not) Positive_regulation (mediated) of BMI associated with obesity
16) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374464 Disease Relevance 1.20 Pain Relevance 0.31
The level of STAT activation increased with the BMI, but the difference between both groups of patients did not reach statistical significance.


Positive_regulation (increased) of BMI associated with obesity
17) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.30 Pain Relevance 0.14
An elevated level of aggrecan mRNA was also found at 500 ng/ml of leptin for both BMI patient groups, but the difference with unstimulated cells did not reach statistical significance.
Positive_regulation (elevated) of BMI associated with obesity
18) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.76 Pain Relevance 0.07
With increases in BMI, FEV1, and FEV1/forced vital capacity (FVC) ratio and diffusion capacity for carbon monoxide significantly increased (P = .007, P = .019, P < .001, resp.), while residual volume (RV), total lung capacity (TLC), and RV/TLC ratio significantly decreased (P = .007, P = .026, P = .029, resp.)
Positive_regulation (increases) of BMI in lung associated with obesity
19) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.24 Pain Relevance 0.04
Limb alignment was found to be strongly associated with risk for progression, which was aggravated by an increase in weight (for each 2 kg/m2 increase in body mass index [BMI]: odds ratio for progression = 1.08, 95% confidence interval [CI] = 1.00–1.16).
Positive_regulation (increase) of BMI in body associated with obesity
20) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 1.07 Pain Relevance 0.26

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