INT171263

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.57
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TNFSF12, MMP1) cell differentiation (TNFSF12) peptidase activity (MMP1)
signal transduction (TNFSF12) extracellular space (TNFSF12) proteinaceous extracellular matrix (MMP1)
TNFSF12 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 89.16 High High
Inflammation 38 35.72 Quite Low
chemokine 22 34.72 Quite Low
metalloproteinase 12 26.04 Quite Low
cytokine 22 21.12 Low Low
Inflammatory response 6 9.28 Low Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
Freund adjuvant 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 88.76 High High
Adhesions 4 67.40 Quite High
Death 12 63.48 Quite High
Cancer 8 53.40 Quite High
Disease 16 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
hTWEAK Positive_regulation (induced) of MMP-1
1) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04
Moreover, blocking anti-TNF antibodies were inactive in the secretion of IL-8, MMP-1, PGE2, RANTES and IP-10 induced by TWEAK, ruling out any involvement of TNF in TWEAK activity.
TWEAK Positive_regulation (induced) of MMP-1
2) Confidence 0.00 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.19 Pain Relevance 0.04

General Comments

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