INT171264

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Context Info
Confidence 0.10
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.05
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TNF, MMP1) intracellular (TNF) extracellular matrix organization (TNF)
extracellular space (TNF) signal transduction (TNF) peptidase activity (MMP1)
TNF (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 33 92.72 High High
Inflammatory mediators 1 89.16 High High
cytokine 32 85.20 High High
Inflammation 38 75.52 Quite High
fibrosis 8 75.00 Quite High
metalloproteinase 6 26.04 Quite Low
chemokine 16 16.56 Low Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 77 98.40 Very High Very High Very High
Pancreatitis 33 92.72 High High
Sepsis 15 89.32 High High
INFLAMMATION 41 88.76 High High
Fibrosis 21 75.00 Quite High
Adhesions 2 67.40 Quite High
Death 6 63.48 Quite High
Cancer 4 53.40 Quite High
Disease 10 5.00 Very Low Very Low Very Low
Cirrhosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
TNF Positive_regulation (induced) of MMP-1
1) Confidence 0.10 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04
LPS and TNFalpha induced collagen1 and fibronectin levels as well as the matrix degradation enzyme MMP-1.
TNFalpha Positive_regulation (induced) of MMP-1
2) Confidence 0.02 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2234395 Disease Relevance 1.67 Pain Relevance 0.90

General Comments

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