INT171266

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Context Info
Confidence 0.11
First Reported 2002
Last Reported 2002
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, CXCL10) extracellular space (TNF, CXCL10) extracellular region (TNF, CXCL10)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 22 99.50 Very High Very High Very High
Inflammation 38 94.16 High High
cytokine 22 44.88 Quite Low
metalloproteinase 12 43.76 Quite Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
Freund adjuvant 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 94.16 High High
Disease 16 83.36 Quite High
Death 12 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, TNF together with TWEAK increased the production of IP-10 69-fold and that of RANTES 46-fold, while IL-1 together with TWEAK enhanced RANTES production 35-fold.
TNF Positive_regulation (increased) of Gene_expression (production) of IP-10
1) Confidence 0.11 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0 Pain Relevance 0
In all the synoviocyte experiments, hTWEAK differed markedly from TNF in the chemokine profile induction since TNF failed consistently to stimulate the expression of RANTES, IP-10 and MIP-1?
TNF Neg (failed) Positive_regulation (stimulate) of Gene_expression (expression) of IP-10 associated with chemokine
2) Confidence 0.09 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.48 Pain Relevance 0.35

General Comments

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