INT171271

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.44
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF12, IL8) extracellular space (TNFSF12, IL8) extracellular region (TNFSF12, IL8)
cell differentiation (TNFSF12) intracellular (IL8) plasma membrane (TNFSF12)
Anatomy Link Frequency
fibroblasts 2
TNFSF12 (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 22 100.00 Very High Very High Very High
Inflammatory response 6 85.36 High High
Inflammation 38 78.72 Quite High
Inflammatory mediators 2 45.88 Quite Low
cytokine 22 41.84 Quite Low
COX2 4 30.88 Quite Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
Freund adjuvant 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 85.36 High High
Disease 16 69.04 Quite High
Adhesions 4 24.12 Low Low
Death 12 20.20 Low Low
Cancer 8 10.12 Low Low
Arthritis 10 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In synoviocytes, BEB3-crosslinked hTWEAK increased the mRNA level of IL-8, MCP-1, RANTES, IP-10 and MIP-1?.
hTWEAK Positive_regulation (increased) of Transcription (level) of IL-8
1) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.23 Pain Relevance 0.13
In dermal fibroblasts, BEB3-crosslinked hTWEAK was shown to increase the mRNA level of three chemokines of the CXC or CC families, IL-8, MCP-1 and RANTES.
hTWEAK Positive_regulation (increase) of Transcription (level) of IL-8 in fibroblasts associated with chemokine
2) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.21 Pain Relevance 0.12

General Comments

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