INT171274

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2002
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TNF, MMP1) intracellular (TNF) extracellular matrix organization (TNF)
extracellular space (TNF) signal transduction (TNF) peptidase activity (MMP1)
Anatomy Link Frequency
fibroblasts 2
TNF (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 11 50.80 Quite High
Inflammation 19 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Freund adjuvant 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 21 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of a blocking mAb to TNF showed that TNF is not involved in the TWEAK-induced production of IL-8, MMP-1, PGE2, RANTES and IP-10 in dermal fibroblasts (Table 2) and in synoviocytes (Table 3).
TNF Neg (not) Regulation (involved) of Gene_expression (production) of MMP-1 in fibroblasts
1) Confidence 0.06 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0 Pain Relevance 0.03

General Comments

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