INT171278

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Context Info
Confidence 0.02
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.93
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFSF12, CCL5) extracellular region (TNFSF12, CCL5) cell differentiation (TNFSF12)
aging (CCL5) cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
fibroblasts 1
TNFSF12 (Homo sapiens)
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 55 96.56 Very High Very High Very High
Inflammatory mediators 5 88.40 High High
Inflammatory response 15 86.56 High High
Inflammation 95 79.92 Quite High
metalloproteinase 30 61.56 Quite High
cytokine 55 43.04 Quite Low
COX2 10 32.08 Quite Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
Freund adjuvant 10 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 105 88.00 High High
Disease 40 70.24 Quite High
Adhesions 10 66.64 Quite High
Death 30 62.72 Quite High
Cancer 20 52.64 Quite High
Arthritis 25 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Necrosis 15 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 15 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In synoviocytes, TWEAK induced RANTES 256-fold and IP-10 19-fold (compared to TNF-?
TWEAK Positive_regulation (induced) of RANTES
1) Confidence 0.02 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.06 Pain Relevance 0.12
Figure 3 shows that hTWEAK induced the mRNAs for RANTES, IL-8 and MCP-1 in dermal fibroblasts.
hTWEAK Positive_regulation (induced) of RANTES in fibroblasts
2) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.07 Pain Relevance 0.15
In synoviocytes, BEB3-crosslinked hTWEAK increased the mRNA level of IL-8, MCP-1, RANTES, IP-10 and MIP-1?.
hTWEAK Positive_regulation (increased) of RANTES
3) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.24 Pain Relevance 0.13
Moreover, blocking anti-TNF antibodies were inactive in the secretion of IL-8, MMP-1, PGE2, RANTES and IP-10 induced by TWEAK, ruling out any involvement of TNF in TWEAK activity.
TWEAK Positive_regulation (induced) of RANTES
4) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.19 Pain Relevance 0.04
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
hTWEAK Positive_regulation (induced) of RANTES
5) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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