INT171287

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF12, CXCL10) extracellular space (TNFSF12, CXCL10) extracellular region (TNFSF12, CXCL10)
cell differentiation (TNFSF12) plasma membrane (TNFSF12) cell-cell signaling (CXCL10)
TNFSF12 (Homo sapiens)
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 33 96.56 Very High Very High Very High
Inflammatory mediators 3 87.96 High High
Inflammatory response 9 87.12 High High
Inflammation 57 80.48 Quite High
cytokine 33 43.60 Quite Low
COX2 6 32.64 Quite Low
metalloproteinase 18 24.84 Low Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Freund adjuvant 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 63 87.56 High High
Disease 24 70.80 Quite High
Adhesions 6 66.20 Quite High
Death 18 62.28 Quite High
Cancer 12 52.20 Quite High
Arthritis 15 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low
Necrosis 9 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
hTWEAK Positive_regulation (induced) of IP-10
1) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04
In synoviocytes, BEB3-crosslinked hTWEAK increased the mRNA level of IL-8, MCP-1, RANTES, IP-10 and MIP-1?.
hTWEAK Positive_regulation (increased) of IP-10
2) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.24 Pain Relevance 0.13
Moreover, blocking anti-TNF antibodies were inactive in the secretion of IL-8, MMP-1, PGE2, RANTES and IP-10 induced by TWEAK, ruling out any involvement of TNF in TWEAK activity.
TWEAK Positive_regulation (induced) of IP-10
3) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.18 Pain Relevance 0.04

General Comments

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