INT171293

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Context Info
Confidence 0.09
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, CXCL10) extracellular space (TNF, CXCL10) extracellular region (TNF, CXCL10)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
T lymphocytes 1
TNF (Homo sapiens)
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 96.12 Very High Very High Very High
chemokine 21 92.44 High High
Inflammatory mediators 1 87.96 High High
antagonist 3 83.04 Quite High
cytokine 18 73.64 Quite High
Inflammatory marker 2 50.00 Quite Low
metalloproteinase 6 24.84 Low Low
Inflammatory response 4 24.40 Low Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 96.12 Very High Very High Very High
Contact Dermatitis 28 90.68 High High
Dermatitis 4 80.92 Quite High
Hypersensitivity 11 67.12 Quite High
Adhesions 6 66.20 Quite High
Death 6 62.28 Quite High
Cancer 4 52.20 Quite High
Disease 11 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
TNF Positive_regulation (induced) of IP-10
1) Confidence 0.09 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04
But here IL-4 exerts a proinflammatory function on keratinocytes by potentiating IFN-gamma and TNF-alpha induction of IP-10, Mig, and I-TAC, which in turn may determine a prominent recruitment of CXCR3+ T lymphocytes at inflammatory reaction sites.
TNF-alpha Positive_regulation (induction) of IP-10 in T lymphocytes associated with inflammation
2) Confidence 0.03 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.60 Pain Relevance 0.27

General Comments

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