INT171296

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.87
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF12, IL8) extracellular space (TNFSF12, IL8) extracellular region (TNFSF12, IL8)
cell differentiation (TNFSF12) intracellular (IL8) plasma membrane (TNFSF12)
Anatomy Link Frequency
fibroblasts 1
TNFSF12 (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 44 96.56 Very High Very High Very High
Inflammatory mediators 4 88.88 High High
Inflammatory response 12 85.36 High High
Inflammation 76 78.72 Quite High
cytokine 44 41.84 Quite Low
COX2 8 30.88 Quite Low
metalloproteinase 24 25.76 Quite Low
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
Freund adjuvant 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 84 88.48 High High
Disease 32 69.04 Quite High
Adhesions 8 67.12 Quite High
Death 24 63.20 Quite High
Cancer 16 53.12 Quite High
Arthritis 20 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Necrosis 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 12 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
hTWEAK Positive_regulation (induced) of IL-8
1) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.38 Pain Relevance 0.04
In synoviocytes, BEB3-crosslinked hTWEAK increased the mRNA level of IL-8, MCP-1, RANTES, IP-10 and MIP-1?.
hTWEAK Positive_regulation (increased) of IL-8
2) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.23 Pain Relevance 0.13
Figure 3 shows that hTWEAK induced the mRNAs for RANTES, IL-8 and MCP-1 in dermal fibroblasts.
hTWEAK Positive_regulation (induced) of IL-8 in fibroblasts
3) Confidence 0.00 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.07 Pain Relevance 0.15
Moreover, blocking anti-TNF antibodies were inactive in the secretion of IL-8, MMP-1, PGE2, RANTES and IP-10 induced by TWEAK, ruling out any involvement of TNF in TWEAK activity.
TWEAK Positive_regulation (induced) of IL-8
4) Confidence 0.00 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.19 Pain Relevance 0.04

General Comments

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