INT171362

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.36
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Raf1) signal transduction (Raf1) plasma membrane (Raf1)
cytoskeleton organization (Raf1) kinase activity (Raf1) cytoplasm (Raf1)
Anatomy Link Frequency
lung 2
spleen 1
T cells 1
Raf1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 22 99.12 Very High Very High Very High
Opioid 23 50.00 Quite Low
opioid receptor 12 41.16 Quite Low
agonist 8 26.56 Quite Low
antagonist 14 24.16 Low Low
substance P 2 18.56 Low Low
tolerance 21 9.04 Low Low
imagery 19 5.00 Very Low Very Low Very Low
Kinase C 15 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 311 99.98 Very High Very High Very High
Apoptosis 9 99.52 Very High Very High Very High
Adenoma 70 99.44 Very High Very High Very High
Cancer 423 99.24 Very High Very High Very High
Colon Cancer 12 99.24 Very High Very High Very High
Skin Cancer 32 97.88 Very High Very High Very High
Targeted Disruption 93 95.60 Very High Very High Very High
Thymoma 10 95.12 Very High Very High Very High
Lung Cancer 40 94.84 High High
Immunization 130 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Construction of a C-Raf overexpressing EL-4 cell line
Gene_expression (overexpressing) of C-Raf
1) Confidence 0.66 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.39 Pain Relevance 0.18
C-Raf is highly expressed in ELRaf cells (data not shown).


Gene_expression (expressed) of C-Raf
2) Confidence 0.66 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.29 Pain Relevance 0.14
In order to achieve stable expression of C-Raf we used the E. coli ?
Gene_expression (expression) of C-Raf
3) Confidence 0.66 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.49 Pain Relevance 0
In order to create tools for analysis of C-Raf specific T cells we first constructed a C-Raf overexpressing EL-4 cell line (ELRaf).
Gene_expression (overexpressing) of C-Raf in T cells
4) Confidence 0.66 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.35 Pain Relevance 0.17
Significant reductions from baseline were detected in the expression of c-raf1 [92].
Gene_expression (expression) of c-raf1
5) Confidence 0.58 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.93 Pain Relevance 0
g/ml Brefeldin A at 37°C, 5% CO2, 1 × 106 spleen cells were incubated for 5 hours with 5 × 105 C-Raf overexpressing EL-4 cells (EL-Raf) or 5 × 105 EL-4 cells or with the addition of 10 ng/ml of phorbol myristyl acetate (PMA; Sigma) and 500 ng/ml of ionomycin (Sigma) or with medium alone.


Gene_expression (overexpressing) of C-Raf in spleen
6) Confidence 0.51 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0 Pain Relevance 0
In addition, overexpression of C-Raf was found in many tumors [5,6].
Gene_expression (overexpression) of C-Raf associated with cancer
7) Confidence 0.51 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 0.56 Pain Relevance 0
Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice

Background

Gene_expression (expressing) of C-Raf in lung associated with adenoma and sprains and strains
8) Confidence 0.51 Published 2005 Journal BMC Cancer Section Title Doc Link PMC549196 Disease Relevance 1.02 Pain Relevance 0
C-Raf antigen was successfully expressed in secreted form by an attenuated Salmonella enterica serovar Typhimurium aroA strain using the E. coli hemolysin secretion system.
Gene_expression (expressed) of C-Raf associated with sprains and strains
9) Confidence 0.51 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC549196 Disease Relevance 1.58 Pain Relevance 0
Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice

Background

Gene_expression (expressing) of C-Raf in lung associated with adenoma and sprains and strains
10) Confidence 0.51 Published 2005 Journal BMC Cancer Section Title Doc Link PMC549196 Disease Relevance 0.96 Pain Relevance 0
Taken together we have demonstrated that the C-Raf antigen can be successfully expressed and secreted by the attenuated Salmonella enterica serovar Typhimurium aroA SL7207 strain via the E. coli hemolysin secretion system.
Gene_expression (expressed) of C-Raf associated with sprains and strains
11) Confidence 0.51 Published 2005 Journal BMC Cancer Section Body Doc Link PMC549196 Disease Relevance 1.42 Pain Relevance 0
Decreased expression levels of RAF1 demonstrate that PU-H71 inhibition of Hsp90 also inhibits the MAPK signaling pathway, consequently suppressing the transcription of genes associated with cell survival, angiogenesis, proliferation, migration, mitosis, and differentiation.
Gene_expression (expression) of RAF1
12) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.22 Pain Relevance 0
0.25 µM, decreased expression levels of Hsp90 client onco-proteins including HER2/neu, Akt and RAF1, compared to DMSO-treated controls.
Gene_expression (expression) of RAF1
13) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.16 Pain Relevance 0
Despite numerous reported differences, it does appear that diverse GPCRs share common mechanistic themes during ERK stimulation, including the tyrosine-phosphorylation of Shc and its complexing with Grb2, mSOS recruitment, the GTP-loading of Ras, and Raf-1 activation leading to MEK-1 phosphorylation [1].
Gene_expression (loading) of Raf-1
14) Confidence 0.05 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0

General Comments

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