INT171364

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.98
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pdgfrb) plasma membrane (Pdgfrb) nucleus (Pdgfrb)
kinase activity (Pdgfrb) lysosome (Pdgfrb) cytoplasm (Pdgfrb)
Pdgfrb (Mus musculus)
Pdgfrb - T674I (1)
Pain Link Frequency Relevance Heat
Opioid 23 95.28 Very High Very High Very High
antagonist 18 95.24 Very High Very High Very High
fibrosis 19 94.88 High High
Taxol 14 86.68 High High
cytokine 10 60.08 Quite High
Inflammation 9 59.68 Quite High
opioid receptor 12 47.80 Quite Low
Inflammatory response 1 46.48 Quite Low
cINOD 1 40.60 Quite Low
Antiemetics 2 36.84 Quite Low
Disease Link Frequency Relevance Heat
Cancer 200 99.96 Very High Very High Very High
Fibrosis 19 98.48 Very High Very High Very High
Pressure And Volume Under Development 48 96.64 Very High Very High Very High
Pulmonary Fibrosis 8 94.88 High High
Glioma 22 93.68 High High
Targeted Disruption 7 92.96 High High
Death 5 87.48 High High
Syndrome 8 86.92 High High
Heart Rate Under Development 18 80.24 Quite High
Blast Crisis 38 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simultaneous targeting of VEGFR and PDGFR kinase activity may be a useful strategy to decrease tumor IFP, but the timing of the inhibitors should be carefully determined.



Localization (decrease) of PDGFR associated with cancer
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2781164 Disease Relevance 0.80 Pain Relevance 0.04
Moreover, inhibiting the PDGF pathway with neutralising antibodies to PDGF or administration of soluble extracellular region of PDGFR-?
Localization (region) of PDGFR
2) Confidence 0.36 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.95 Pain Relevance 0.32
Potential of endogenously expressed insulin receptors (IR) and PDGFR to act as surrogate protein scaffolds during ERK activation by ?
Localization (act) of PDGFR
3) Confidence 0.32 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.24 Pain Relevance 0.32
In light of these results the presence of a less sensitive mutation like Exon 9 or of a wild-type KIT/PDGFR?
Localization (type) of PDGFR
4) Confidence 0.30 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.75 Pain Relevance 0
Mice with homozygous deletions of PDGF-B or PDGFR-?
Localization (deletions) of PDGFR
5) Confidence 0.21 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 2.19 Pain Relevance 0
The clinically important Thr315Ile mutation is viewed to be homolog to the Thr670Ile mutation in c-Kit, Thr674Ile in PDGFR-?
Localization (mutation) of PDGFR (T674I)
6) Confidence 0.18 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.06 Pain Relevance 0

General Comments

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