INT171367

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 31
Total Number 44
Disease Relevance 32.87
Pain Relevance 8.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Map2k1) cytoplasm (Map2k1) cytosol (Map2k1)
cell proliferation (Map2k1) mitosis (Map2k1) cell motility (Map2k1)
Anatomy Link Frequency
colon 2
nodule 2
cleavage 1
brain 1
prefrontal 1
Map2k1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1036 99.56 Very High Very High Very High
Hippocampus 88 99.40 Very High Very High Very High
amygdala 48 97.68 Very High Very High Very High
Bile 20 93.80 High High
Arthritis 140 91.48 High High
imagery 25 90.36 High High
Inflammation 111 89.36 High High
cytokine 79 88.32 High High
spinal inflammation 140 81.52 Quite High
Kinase C 14 56.28 Quite High
Disease Link Frequency Relevance Heat
Cancer 1623 99.84 Very High Very High Very High
Colon Cancer 184 99.60 Very High Very High Very High
Rheumatoid Arthritis 1036 99.56 Very High Very High Very High
Hepatocellular Cancer 684 99.32 Very High Very High Very High
Liver Cancer 228 98.72 Very High Very High Very High
Malignant Neoplastic Disease 45 98.56 Very High Very High Very High
Stress 278 98.38 Very High Very High Very High
Cirrhosis 96 97.68 Very High Very High Very High
Apoptosis 785 97.40 Very High Very High Very High
Disease 114 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry analysis of a colorectal cancer tissue microarray containing over 400 colorectal cancer and 50 normal colon tissue biopsies revealed that 44% of colorectal cancers display high cytoplasmic expression of phosphorylated MEK1/MEK2 as compared to 10% of normal tissues (analysis to be published elsewhere).
Phosphorylation (phosphorylated) of MEK1 in colon associated with colon cancer
1) Confidence 0.58 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.52 Pain Relevance 0
Immunoblot analysis under electrophoresis conditions that partially resolve the two isoforms indicates that both MEK1 and MEK2 are phosphorylated in human colon carcinoma cell lines (Fig. 6A).
Phosphorylation (phosphorylated) of MEK1 in colon associated with colon cancer
2) Confidence 0.58 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.85 Pain Relevance 0
The best-characterized of the Ras effector pathways is the activation of the Raf family Ser/Thr kinases, leading to sequential phosphorylation and activation of MEK1/MEK2 and the mitogen-activated protein (MAP) kinases ERK1/ERK2 [8].
Phosphorylation (phosphorylation) of MEK1
3) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.89 Pain Relevance 0
However, immunoblot analysis clearly indicates that HT-29 cells express more phosphorylated MEK1 (lower band in upper panel of Fig. 6A) than MEK2, arguing that quantitative difference in expression levels does not explain everything.
Phosphorylation (phosphorylated) of MEK1 in HT-29
4) Confidence 0.44 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.48 Pain Relevance 0.03
For phosphorylated MEK1/2, tumors were scored as 1 (<1.0% of tumor cells positive); 2 (1–5% of tumor cells positive); 3 (5–10% of tumor cells positive) and 4 (>10% of tumor cells positive).
Phosphorylation (phosphorylated) of MEK1 associated with cancer
5) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.18 Pain Relevance 0
Immunostaining of the blots displayed a marked increase in phosphorylated MEK1/2 (Fig. 2A, 2B &2C).
Phosphorylation (phosphorylated) of MEK1
6) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.33 Pain Relevance 0
A summary of the immunohistochemical analysis of MEK1/2 phosphorylation in human HCCs is shown in table 1.
Phosphorylation (phosphorylation) of MEK1
7) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.67 Pain Relevance 0.05
In summary, we have shown that high expression levels of MAPK, phosphorylated MAPK and phosphorylated MEK1/2 are found in tumors of HCC patients.
Phosphorylation (phosphorylated) of MEK1 associated with cancer and hepatocellular cancer
8) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.37 Pain Relevance 0
The percentage of cells showing positively for phosphorylated MEK1/2 appears to increase with advancing tumor stage.
Phosphorylation (phosphorylated) of MEK1 associated with cancer
9) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.75 Pain Relevance 0.04
HCC tumors are heterogeneous with respect to cell-type, and therefore it was critical to identify the cell-type responsible for the elevation of phosphorylated MEK1/2 and MAPK.
Phosphorylation (phosphorylated) of MEK1 associated with cancer and hepatocellular cancer
10) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.35 Pain Relevance 0.03
An antibody specific for phosphorylated MEK1/2 at serine (Ser217/221) was used to stain the tissue sections.
Phosphorylation (phosphorylated) of MEK1
11) Confidence 0.37 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.39 Pain Relevance 0.04
While MEK 1/2 was heavily phosphorylated on serine 217/221 in 100% (46/46) of HCCs, ABL tissues of the same patients showed little phosphorylated MEK1/2 under the same conditions (Fig. 2A, 2B &2C).
Neg (little) Phosphorylation (phosphorylated) of MEK1
12) Confidence 0.36 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.31 Pain Relevance 0
After blocking endogenous peroxidase activity and reducing nonspecific background staining, the sections were incubated with the primary antisera against phosphorylated MEK1/2 (Ser217/221) or phosphorylated MAPK (Thr202/Tyr204) (overnight at 4°C).
Phosphorylation (phosphorylated) of MEK1
13) Confidence 0.36 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.31 Pain Relevance 0
After blocking endogenous peroxidase activity and reducing nonspecific background staining, the sections were incubated with the primary antisera against phosphorylated MEK1/2 (Ser217/221) or phosphorylated MAPK (Thr202/Tyr204) (overnight at 4°C).
Phosphorylation (phosphorylated) of MEK1
14) Confidence 0.36 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.37 Pain Relevance 0
We found that anti-BRAF autoantibodies activate the in vitro phosphorylation of MEK1 mediated by BRAF.


Phosphorylation (phosphorylation) of MEK1
15) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 1.17 Pain Relevance 0.67
To test whether autoantibodies to BRAF influence BRAF kinase activity, we developed a phosphorylation assay with BRAF, its substrate MEK1 and purified anti-BRAF autoantibodies from RA patients.
Phosphorylation (phosphorylation) of MEK1 associated with rheumatoid arthritis
16) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.88 Pain Relevance 0.50
We observed that 65% of anti-BRAF autoantibodies activate phosphorylation of MEK1 by BRAF in vitro.
Phosphorylation (phosphorylation) of MEK1
17) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.81 Pain Relevance 0.49
phosphorylated S298 of MEK1 that supports its activity [23].
Phosphorylation (phosphorylated) of MEK1
18) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.33 Pain Relevance 0
We report that phosphorylation of MEK1/2 at Ser217/221 was detected by immuno-histochemistry in 100% (46 of 46) of HCCs examined.
Phosphorylation (phosphorylation) of MEK1
19) Confidence 0.28 Published 2003 Journal BMC Gastroenterol Section Abstract Doc Link PMC317301 Disease Relevance 0.75 Pain Relevance 0
Approximately 7-fold increase in MEK1/2 phosphorylation was detected in HCC as compared with ABL tissues (Fig. 2D).
Phosphorylation (phosphorylation) of MEK1 associated with hepatocellular cancer
20) Confidence 0.28 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.29 Pain Relevance 0

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