INT171372

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.82
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
margin 2
HGF 2
endometrium 2
Egf (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 32 86.16 High High
cytokine 30 85.40 High High
Opioid 46 80.56 Quite High
cINOD 73 79.60 Quite High
Pyramidal cell 4 72.80 Quite High
Inflammation 65 72.24 Quite High
fibrosis 16 64.24 Quite High
monoamine 13 58.76 Quite High
Hippocampus 14 58.24 Quite High
opioid receptor 24 50.12 Quite High
Disease Link Frequency Relevance Heat
Cancer 385 99.88 Very High Very High Very High
Wound Healing 34 99.80 Very High Very High Very High
Adenocarcinoma 33 99.44 Very High Very High Very High
Targeted Disruption 174 99.42 Very High Very High Very High
Ulcers 200 99.28 Very High Very High Very High
Metastasis 42 99.24 Very High Very High Very High
Noninfiltrating Intraductal Carcinoma 5 99.24 Very High Very High Very High
Breast Cancer 50 97.32 Very High Very High Very High
Death 69 96.28 Very High Very High Very High
Cicatrix 63 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF is also reported to stimulate PG synthesis, which, in turn, augments the expression of EGF via a feedback cycle, mediated by the PKA signaling pathway [34].
Positive_regulation (augments) of Gene_expression (expression) of EGF
1) Confidence 0.66 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.45 Pain Relevance 0.08
However, treatment with PK for one and three days augmented the expression of EGF further by 98.1% and 149.0% (P < 0.001) compared to that in the respective ulcerated control mice.
Positive_regulation (augmented) of Gene_expression (expression) of EGF
2) Confidence 0.66 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.09 Pain Relevance 0
PK showed significantly better effect than Omez (P < 0.01), which increased the EGF expression by 11.6% compared to that of group III mice.
Positive_regulation (increased) of Gene_expression (expression) of EGF
3) Confidence 0.66 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.08 Pain Relevance 0
Compared to the normal mice, the expressions of EGF increased by ~2.7 and 3.6 folds respectively (P < 0.001) for the groups II and III ulcerated mice.
Positive_regulation (increased) of Gene_expression (expressions) of EGF
4) Confidence 0.66 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.09 Pain Relevance 0
Administration of the test drugs led to an increased expression of EGF in mucosa of the ulcer margin.
Positive_regulation (increased) of Gene_expression (expression) of EGF in margin associated with ulcers
5) Confidence 0.66 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.10 Pain Relevance 0
In addition, overexpression of EGF was correlated with tumor progression and extensive metastasis in breast cancers [10], and other malignancies [11].
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGF associated with cancer, breast cancer and metastasis
6) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2254193 Disease Relevance 1.86 Pain Relevance 0.03
Effect of PK and Omez on EGF expression
Positive_regulation (on) of Gene_expression (expression) of EGF
7) Confidence 0.47 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2266895 Disease Relevance 0.09 Pain Relevance 0
Special attention was focused when a study by Pedal et al. (10) showed that EGF was involved in scarless wound healing in which increased expression of EGF in the early murine fetal period was found and decreased EGF expression was noted during the scar formation at late pregnancy.
Positive_regulation (increased) of Gene_expression (expression) of EGF associated with cicatrix and wound healing
8) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844601 Disease Relevance 1.32 Pain Relevance 0.11
On the other hand, we did not detect significant differences between controls and KO mice regarding the relative expression of other EGF family growth factors, such as EGF [Control; 100±4.58 (mean±S.E.M., n?
Positive_regulation (as) of Gene_expression (expression) of EGF associated with targeted disruption
9) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 1.01 Pain Relevance 0.06
A marked increase in the expression of human EGF receptor has proven to be associated with advanced tumour stage and significantly shorter survival [23].
Positive_regulation (increase) of Gene_expression (expression) of EGF associated with cancer
10) Confidence 0.27 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.07 Pain Relevance 0
The presence of MSC within the tumor also enhanced expression of growth factors such as EGF and HGF.
Positive_regulation (enhanced) of Gene_expression (expression) of EGF in HGF associated with cancer
11) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 1.27 Pain Relevance 0
Concomitant expression of epidermal growth factor receptor (EGFR) with its ligand, such as EGF, transforming growth factor ?
Positive_regulation (transforming) of Gene_expression (expression) of EGF
12) Confidence 0.21 Published 2006 Journal J Carcinog Section Body Doc Link PMC1559682 Disease Relevance 1.51 Pain Relevance 0.03
Similar to DSLET, EGF (5 ng/ml) produces a robust activation of ERKs in ?
Positive_regulation (activation) of Gene_expression (produces) of EGF
13) Confidence 0.18 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.26
PTX did not attenuate EGF-mediated ERK activation (Figure 2a), although this response was completely blocked by the EGFR kinase inhibitor, AG1478 (1 ?
Positive_regulation (mediated) of Gene_expression (activation) of EGF
14) Confidence 0.18 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.23
Upregulated production of angiogenic factors including PDGF, EGF, and VEGF have been described both in the mouse and human endometrium [55,56].
Positive_regulation (Upregulated) of Gene_expression (production) of EGF in endometrium
15) Confidence 0.11 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0 Pain Relevance 0
One is the overexpression of growth factors with mitogenic/differentiation activity, such as NGF, IGF-1/2 and Epidermal Growth factor (EGF), as well Tumor Growth Factor-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of EGF associated with cancer
16) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.89 Pain Relevance 0.04

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