INT171373

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Context Info
Confidence 0.14
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.67
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Raf1) signal transduction (Raf1) plasma membrane (Raf1)
cytoskeleton organization (Raf1) kinase activity (Raf1) cytoplasm (Raf1)
Anatomy Link Frequency
epithelial cells 1
Raf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 70.60 Quite High
Paracetamol 122 65.72 Quite High
Opioid 23 50.00 Quite Low
opioid receptor 12 40.36 Quite Low
Multiple sclerosis 3 32.16 Quite Low
agonist 8 27.44 Quite Low
antagonist 14 23.36 Low Low
substance P 2 19.44 Low Low
Central nervous system 1 11.36 Low Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 45 88.56 High High
Cancer 37 68.40 Quite High
Viral Infection 1 37.76 Quite Low
Autoimmune Disease 1 34.72 Quite Low
Demyelinating Disease 3 32.16 Quite Low
Metastasis 10 12.56 Low Low
Glioma 13 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Intestinal Cancer 8 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, IFN-receptor dimerization can directly activate PI 3-kinase/Akt, Raf-1/ERK and p38 MAP kinase pathways.
Positive_regulation (activate) of Raf-1
1) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0 Pain Relevance 0.10
Despite numerous reported differences, it does appear that diverse GPCRs share common mechanistic themes during ERK stimulation, including the tyrosine-phosphorylation of Shc and its complexing with Grb2, mSOS recruitment, the GTP-loading of Ras, and Raf-1 activation leading to MEK-1 phosphorylation [1].
Positive_regulation (activation) of Raf-1
2) Confidence 0.09 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0
Intriguingly, it was also reported that activated Ras, but not Raf-1, causes transformation of mammary and intestinal epithelial cells, suggesting that signaling events other than activation of MEK1/2 are essential for oncogenic Ras transformation [57].
Neg (not) Positive_regulation (activated) of Raf-1 in epithelial cells
3) Confidence 0.09 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.67 Pain Relevance 0

General Comments

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