INT171376

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.05
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
macrophages 4
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 10 99.60 Very High Very High Very High
cytokine 35 99.00 Very High Very High Very High
metalloproteinase 64 98.64 Very High Very High Very High
Opioid 23 94.96 High High
antagonist 14 85.20 High High
Inflammation 86 57.64 Quite High
Hippocampus 10 49.04 Quite Low
cerebral cortex 3 48.24 Quite Low
Pyramidal cell 2 43.76 Quite Low
opioid receptor 12 41.44 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 36 100.00 Very High Very High Very High
Obesity 254 99.88 Very High Very High Very High
Diabetes Mellitus 62 97.28 Very High Very High Very High
Disease 102 95.92 Very High Very High Very High
Hyperinsulinism 12 87.32 High High
Glioma 13 84.88 Quite High
Cognitive Disorder 8 59.24 Quite High
INFLAMMATION 96 57.64 Quite High
Dementia 15 50.00 Quite Low
Insulin Resistance 75 22.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Positive_regulation (increased) of Phosphorylation (apoptosis) of Insulin receptor in macrophages associated with metalloproteinase and apoptosis
1) Confidence 0.31 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.24 Pain Relevance 0.23
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Positive_regulation (induced) of Phosphorylation (apoptosis) of Insulin receptor in macrophages associated with metalloproteinase and apoptosis
2) Confidence 0.31 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.24 Pain Relevance 0.23
M, neither DSLET, DADLE, nor DPDPE were found to increase the tyrosine phosphorylation of the IR or the PDGFR, whereas insulin (100 ng/ml) or PDGF (50 ng/ml) induced significant tyrosine phosphorylation of these sites (Figure 8).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of IR
3) Confidence 0.07 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.14 Pain Relevance 0.40
Insulin and IGF1 receptors are tyrosine kinases that mediate the phosphorylation of insulin receptor substrates (IRSs) including IRS1-4.
Positive_regulation (mediate) of Phosphorylation (phosphorylation) of insulin receptor
4) Confidence 0.05 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.43 Pain Relevance 0

General Comments

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