INT171378

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.48
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) Golgi apparatus (Egfr)
endoplasmic reticulum (Egfr) intracellular (Egfr) enzyme binding (Egfr)
Egfr (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 23 93.40 High High
opioid receptor 12 81.80 Quite High
antagonist 14 53.20 Quite High
adenocard 2 46.48 Quite Low
cytokine 2 45.00 Quite Low
Kinase C 9 14.32 Low Low
agonist 8 5.00 Very Low Very Low Very Low
MU agonist 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 109 99.96 Very High Very High Very High
Glioma 13 99.68 Very High Very High Very High
Reprotox - General 1 39 90.40 High High
Non-small-cell Lung Cancer 66 67.40 Quite High
Metastasis 12 61.48 Quite High
Hyperplasia 5 34.96 Quite Low
Immunotherapy Of Cancer 2 15.20 Low Low
Solid Tumor 2 14.48 Low Low
Stress 9 8.40 Low Low
Apoptosis 25 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DsRNA specific for EGFR inhibited tumor growth in vivo
Negative_regulation (inhibited) of EGFR Binding (specific) of associated with cancer
1) Confidence 0.43 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.61 Pain Relevance 0
DsRNA specific for EGFR also inhibited tumor cell growth
Negative_regulation (inhibited) of EGFR Binding (specific) of associated with cancer
2) Confidence 0.43 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.10 Pain Relevance 0
DSLET activates ERK even in a cell line devoid of the EGFR
Negative_regulation (devoid) of EGFR Binding (line) of
3) Confidence 0.33 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.18 Pain Relevance 0.16
Interference with the EGFR either through prevention of ligand binding, disruption of surface expression, or prohibition of cytosolic protein interaction can inhibit ERK activation.
Negative_regulation (inhibit) of EGFR Binding (Interference) of
4) Confidence 0.22 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.59 Pain Relevance 0

General Comments

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