INT171379

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.32
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) plasma membrane (Lpar1) cytoplasm (Lpar1)
signal transducer activity (Lpar1)
Anatomy Link Frequency
dorsal root 2
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 79 99.40 Very High Very High Very High
spinal dorsal horn 10 89.68 High High
Dorsal horn 9 86.00 High High
opioid receptor 12 80.96 Quite High
Opioid 23 74.88 Quite High
Potency 3 70.76 Quite High
agonist 23 63.80 Quite High
Sciatic nerve 16 60.68 Quite High
antagonist 29 56.08 Quite High
Central nervous system 2 32.96 Quite Low
Disease Link Frequency Relevance Heat
Glioma 13 75.20 Quite High
Ovarian Cancer 24 62.56 Quite High
Urological Neuroanatomy 10 60.40 Quite High
Ganglion Cysts 23 60.20 Quite High
Nervous System Injury 4 50.00 Quite Low
Neuropathic Pain 44 5.00 Very Low Very Low Very Low
Cancer 24 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in LPC-induced LPA was observed with a similar time-course in dorsal root (DR) preparations.
Positive_regulation (increase) of Positive_regulation (increase) of LPA in dorsal root
1) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.29
I.t. injection of LPA (1 nmol) caused a time-dependent increase in LPA levels in the SC and DR that lasted until 3 h post-treatment, followed by a slight decline in LPA levels at 5 h.
Positive_regulation (caused) of Positive_regulation (increase) of LPA associated with spinal cord
2) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.18 Pain Relevance 0.14
This enrichment in the unsaturated species increases the likelihood of the activation of those LPA targets that show preference for these fatty acyl species.
Positive_regulation (increases) of Positive_regulation (activation) of LPA
3) Confidence 0.27 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0.04
In the presence of the EGFR, ligand activation of LPA and ET-1 receptors did not increase EGFR phosphorylation even though both the LPA and ET-1 receptors stimulated ERK activity by 10-fold over basal [27].
Neg (not) Positive_regulation (increase) of Positive_regulation (activation) of LPA
4) Confidence 0.04 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.13 Pain Relevance 0.23

General Comments

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