INT171394

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Grb2, Shc1) cytoplasm (Grb2, Shc1) nucleus (Grb2, Shc1)
cell differentiation (Grb2) endosome (Grb2) mitochondrion (Shc1)
Grb2 (Mus musculus)
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 23 50.00 Quite Low
opioid receptor 12 43.56 Quite Low
antagonist 14 26.56 Quite Low
agonist 8 22.32 Low Low
substance P 2 14.32 Low Low
MU agonist 4 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
orphanin 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 13 5.00 Very Low Very Low Very Low
Bordatella Infection 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite numerous reported differences, it does appear that diverse GPCRs share common mechanistic themes during ERK stimulation, including the tyrosine-phosphorylation of Shc and its complexing with Grb2, mSOS recruitment, the GTP-loading of Ras, and Raf-1 activation leading to MEK-1 phosphorylation [1].
Grb2 Binding (complexing) of Shc
1) Confidence 0.05 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0

General Comments

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