INT171406

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.75
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pklr) carbohydrate metabolic process (Pklr) kinase activity (Pklr)
Anatomy Link Frequency
liver 1
blood cells 1
Pklr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 96.44 Very High Very High Very High
Potency 1 93.12 High High
Inflammation 45 92.48 High High
IPN 6 85.04 High High
Pain 12 82.92 Quite High
qutenza 31 75.56 Quite High
dorsal root ganglion 26 69.36 Quite High
Hyperalgesia 5 61.44 Quite High
withdrawal 8 41.92 Quite Low
agonist 22 37.28 Quite Low
Disease Link Frequency Relevance Heat
Insulin Resistance 50 99.24 Very High Very High Very High
Immunization 12 99.16 Very High Very High Very High
Hyperinsulinism 6 98.52 Very High Very High Very High
INFLAMMATION 49 92.48 High High
Nociception 31 87.20 High High
Inflammatory Pain 6 85.04 High High
Pain 12 82.92 Quite High
Ganglion Cysts 26 69.36 Quite High
Hyperglycemia 6 68.24 Quite High
Diabetes Mellitus 34 64.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Log2 P-K IgE titers of each group are shown in Table 3.
Gene_expression (titers) of P-K
1) Confidence 0.65 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.55 Pain Relevance 0
In contrast, PK1 was not found in the peripheral blood cells [9].
Neg (not) Gene_expression (found) of PK1 in blood cells
2) Confidence 0.38 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.20 Pain Relevance 0.86
Elevated hepatic glucose production in the presence of hyperinsulinemia is a hallmark of insulin resistance in the liver even with the increased expression of the liver specific pyruvate kinase (L-PK), a key regulatory enzyme in converting phosphoenolpyruvate to pyruvate during glycolysis.
Gene_expression (expression) of L-PK in liver associated with hyperinsulinism and insulin resistance
3) Confidence 0.17 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.49 Pain Relevance 0
Increase L-PK gene expression is mediated by glucose activation of the ChREBP transcription factor.
Gene_expression (expression) of L-PK
4) Confidence 0.17 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.51 Pain Relevance 0

General Comments

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