INT171435

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 26.55
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SDHD) mitochondrion (SDHD) small molecule metabolic process (SDHD)
Anatomy Link Frequency
germline 1
SDHD (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 50 87.28 High High
nud 18 86.88 High High
Inflammation 27 86.24 High High
metalloproteinase 7 84.12 Quite High
Pain 14 83.36 Quite High
medulla 11 79.72 Quite High
Bile 9 70.00 Quite High
imagery 25 69.76 Quite High
Somatostatin 5 61.68 Quite High
Enkephalin 3 61.12 Quite High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 351 100.00 Very High Very High Very High
Paraganglioma 208 100.00 Very High Very High Very High
Stomach Cancer 324 99.98 Very High Very High Very High
Pheochromocytoma 81 99.88 Very High Very High Very High
Cancer 183 99.60 Very High Very High Very High
Disease 92 99.50 Very High Very High Very High
Infection 353 99.48 Very High Very High Very High
Sprains And Strains 144 98.98 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 8 98.60 Very High Very High Very High
Von Hippel-lindau Syndrome 3 97.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior to 2000, three different familial and syndromic diseases were known to result in PGL and/or PH: MEN-2 induced by germline inactivating mutations in the RET proto-oncogene; VHL disease due to mutations in the tumor suppressor gene VHL; and NF1 caused by mutations in the NF1 gene.
Gene_expression (/) of PGL in germline associated with cancer, paraganglioma, watson syndrome, disease and pheochromocytoma
1) Confidence 0.58 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 2.42 Pain Relevance 0.08
Due to histopathologic diagnosis, genetic testing for familial paraganglioma, neurofibromatosis type 1, von Hippel-Lindau disease, the Carney triad, multiple endocrine neoplasia type 2, and mutations of the succinate dehydrogenase genes (SDHB, SDHC, and SDHD) was performed that was negative.
Neg (negative) Gene_expression (negative) of SDHD associated with multiple endocrine neoplasia type 2a, von hippel-lindau syndrome, paraganglioma and watson syndrome
2) Confidence 0.39 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 0.73 Pain Relevance 0.43
The four studies examining all three genes included 103 cases and found 3 mutations of SDHB, 0 mutations of SDHC and 7 mutations of SDHD.
Gene_expression (mutations) of SDHD
3) Confidence 0.21 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1343542 Disease Relevance 0.39 Pain Relevance 0
In conclusion, we have shown regression of PGL after surgical resection combined with eradication of H. pylori and development of GC in association with reinfection with H. pylori in the present case.
Gene_expression (regression) of PGL associated with lymphatic system cancer and stomach cancer
4) Confidence 0.13 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC102757 Disease Relevance 1.82 Pain Relevance 0
Accordingly we report a patient with PGL from India in whom surgical resection of the tumor combined with eradication of H. pylori was followed by regression of PGL.
Gene_expression (regression) of PGL associated with lymphatic system cancer and cancer
5) Confidence 0.13 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC102757 Disease Relevance 2.52 Pain Relevance 0.16
Our patient developed GC on follow up after regression of PGL.
Gene_expression (regression) of PGL associated with lymphatic system cancer and stomach cancer
6) Confidence 0.13 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC102757 Disease Relevance 2.02 Pain Relevance 0
Occurrence of metachronous GC after regression of PGL with eradication of H. pylori has been reported rarely [31,32].
Gene_expression (regression) of PGL associated with lymphatic system cancer and stomach cancer
7) Confidence 0.13 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC102757 Disease Relevance 2.86 Pain Relevance 0.04
High index of suspicion is required for early diagnosis of PGL in developing countries.
Gene_expression (diagnosis) of PGL associated with lymphatic system cancer
8) Confidence 0.13 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC102757 Disease Relevance 1.11 Pain Relevance 0
However, this seems less likely as in most cases of combined tumor reported earlier GC and PGL were synchronous in nature [24-29].
Gene_expression (synchronous) of PGL associated with lymphatic system cancer, cancer and stomach cancer
9) Confidence 0.13 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC102757 Disease Relevance 2.80 Pain Relevance 0.04
Four cases of metachronous GC after regression of PGL with H. pylori eradication have been reported till date [31,32].
Gene_expression (regression) of PGL associated with lymphatic system cancer and stomach cancer
10) Confidence 0.13 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC102757 Disease Relevance 2.82 Pain Relevance 0.04
In a single series of 12 cases two developed metachronous tumor in both of whom GC preceded PGL [24].
Gene_expression (preceded) of PGL associated with lymphatic system cancer, cancer and stomach cancer
11) Confidence 0.13 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC102757 Disease Relevance 2.87 Pain Relevance 0.04
Development of GC in our patient was temporally associated with re-infection with H. pylori following regression of PGL.
Gene_expression (regression) of PGL associated with lymphatic system cancer, infection and stomach cancer
12) Confidence 0.13 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC102757 Disease Relevance 2.63 Pain Relevance 0.04
SDHA gene (this is not a PGL gene)
Gene_expression (gene) of PGL
13) Confidence 0.04 Published 2006 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837305 Disease Relevance 1.24 Pain Relevance 0.04
From those, only two proteins (PpsA and FadD28) were not observed in a 1:1 ratio, but still the calculated differences were below our stringent threshold, being 2.5- and 2.8-fold over-represented in the hypovirulent strain, respectively, showing that in principle PDIM and PGL synthesis are expected to be similar in this model.
Gene_expression (synthesis) of PGL associated with sprains and strains
14) Confidence 0.01 Published 2010 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2984234 Disease Relevance 0.17 Pain Relevance 0
The genes that participate in PGL synthesis and modification are located together within the PDIM locus.
Gene_expression (synthesis) of PGL
15) Confidence 0.01 Published 2010 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2984234 Disease Relevance 0.16 Pain Relevance 0

General Comments

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