INT171446

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.93
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Emp1) molecular_function (Emp1) biological_process (Emp1)
Anatomy Link Frequency
arterioles 2
Emp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 41 99.64 Very High Very High Very High
ischemia 20 99.16 Very High Very High Very High
Dynorphin 1 98.36 Very High Very High Very High
Kinase C 1 71.48 Quite High
isoflurane 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
Spinal Cord Ischemia 15 99.64 Very High Very High Very High
Reperfusion Injury 3 98.76 Very High Very High Very High
Injury 12 92.70 High High
Death 2 77.24 Quite High
Frailty 6 74.08 Quite High
Cv Unclassified Under Development 4 45.08 Quite Low
Pressure And Volume Under Development 1 39.36 Quite Low
Necrosis 2 38.52 Quite Low
Middle Cerebral Artery Infarction 5 13.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to pharmacology of TMP and studies for effects of TMP on cerebral ischemic injury, antiplatelet activation and aggregation, dilating arterioles to improve microcirculation [17,18], scavenging free radicals, increasing the activity of SOD and decreasing lipid peroxidation [10], inhibiting calcium overload [9], reducing the production of nitric oxide and dynorphin A1-13 in ischemic tissue [19,20], decreasing the protein expression of c-fos and increasing the protein expression of bcl-2 and heat shock protein 70(HSP 70) [21,22]may be mechanisms for protection of TMP against spinal cord ischemia /reperfusion injury.
Positive_regulation (increasing) of Gene_expression (protection) of TMP in arterioles associated with reperfusion injury, dynorphin, ischemia, shock, injury and spinal cord
1) Confidence 0.37 Published 2002 Journal BMC Neurol Section Body Doc Link PMC107739 Disease Relevance 0.93 Pain Relevance 0.47

General Comments

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