INT17145

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 2005
Negated 1
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 1.39
Pain Relevance 6.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Anatomy Link Frequency
hypothalamus 1
cerebral cortex 1
brain 1
brainstem 1
thalamus 1
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 25 100.00 Very High Very High Very High
dexamethasone 17 100.00 Very High Very High Very High
lidocaine 10 100.00 Very High Very High Very High
Versed 3 100.00 Very High Very High Very High
anesthesia 6 98.66 Very High Very High Very High
Paracetamol 1 98.60 Very High Very High Very High
isoflurane 3 98.44 Very High Very High Very High
halothane 5 97.12 Very High Very High Very High
cerebral cortex 6 96.44 Very High Very High Very High
Clonidine 2 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 2 97.74 Very High Very High Very High
Necrosis 2 96.08 Very High Very High Very High
Cancer 2 91.24 High High
Arthritis 2 85.80 High High
Pain 3 85.20 High High
Experimental Arthritis 4 79.72 Quite High
Hypertension 1 76.40 Quite High
INFLAMMATION 3 75.00 Quite High
Hepatitis 1 75.00 Quite High
Anxiety Disorder 1 69.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical case reports of unexplained hepatic dysfunction following enflurane and isoflurane anesthesia led to the hypothesis that oxidative metabolism of these drugs by cytochromes P-450 produces immunoreactive, covalently bound acylated protein adducts similar to those implicated in the genesis of halothane-induced hepatic necrosis.
cytochromes P-450 Binding (bound) of associated with necrosis, anesthesia, hepatotoxicity, halothane and isoflurane
1) Confidence 0.42 Published 1988 Journal Drug Metab. Dispos. Section Abstract Doc Link 2894942 Disease Relevance 0.27 Pain Relevance 0.34
The changes in the parameters for drug binding to microsomal P450 probably relate to the increased lipid content of the microsomes although changes in the proportion of P450 isoenzymes could be involved.
P450 Binding (binding) of
2) Confidence 0.41 Published 1989 Journal Pharmacology Section Abstract Doc Link 2727049 Disease Relevance 0 Pain Relevance 0.46
Effect of glucose administration on various rat hepatic constituents and on the spectral binding of hexobarbital and methadone to rat hepatic cytochrome P450.
P450 Binding (binding) of associated with methadone
3) Confidence 0.41 Published 1989 Journal Pharmacology Section Title Doc Link 2727049 Disease Relevance 0 Pain Relevance 0.43
The previously observed decrease in the microsomal metabolism of hexobarbital and methadone following glucose treatment may be due to decreased binding of these compounds to microsomal P450.
P450 Binding (binding) of associated with methadone
4) Confidence 0.41 Published 1989 Journal Pharmacology Section Abstract Doc Link 2727049 Disease Relevance 0 Pain Relevance 0.43
Recent in vitro radioligand binding studies have shown that several cytochrome P-450 inhibitors can displace [3H] sigma ligands, suggesting that these ligands might bind to the cytochrome P-450 superfamily of enzymes.
P-450 Spec (might) Binding (bind) of
5) Confidence 0.40 Published 1993 Journal Synapse Section Abstract Doc Link 8427011 Disease Relevance 0 Pain Relevance 0.19
The effect of this glucose treatment on hepatic glycogen and on microsomal protein, cytochrome P450 (P450), cholesterol, lipid and phospholipid content, as well as on the spectral binding of hexobarbital and methadone to microsomal P450, was examined.
P450 Binding (binding) of associated with methadone
6) Confidence 0.35 Published 1989 Journal Pharmacology Section Abstract Doc Link 2727049 Disease Relevance 0 Pain Relevance 0.42
The binding of hexobarbital and methadone by P450 produced a type 1 spectrum in both control and glucose-treated animals.
P450 Binding (binding) of associated with methadone
7) Confidence 0.31 Published 1989 Journal Pharmacology Section Abstract Doc Link 2727049 Disease Relevance 0 Pain Relevance 0.43
These results suggest direct interaction between FK-506 and cytochrome P-450 apoproteins, except for the heme iron regions of cytochromes P-450, resulting in inhibition of the drug-metabolism activities catalyzed by cytochromes P-450.
P-450 Neg (except) Binding (interaction) of
8) Confidence 0.20 Published 1997 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 9304807 Disease Relevance 0 Pain Relevance 0.06
Immunocytochemical localization using antibodies to P-450b,e indicated the presence of P-450 predominantly in the neuronal cell bodies and to a lesser extent in the fibre tracts in cerebral cortex, cerebellum, thalamus, hypothalamus, hippocampus and brainstem.
P-450 Binding (presence) of in hippocampus associated with medulla, hippocampus, thalamus and cerebral cortex
9) Confidence 0.15 Published 1990 Journal Brain Res. Section Abstract Doc Link 2085761 Disease Relevance 0 Pain Relevance 0.27
These results indicate that testosterone may regulate the forms of cerebral P-450 that are associated with the sex-related difference observed in rat brain.
P-450 Binding (associated) of in brain
10) Confidence 0.15 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1881602 Disease Relevance 0 Pain Relevance 0.15
These results show that the interaction between lidocaine and midazolam and thiamylal, catalyzed by a similar cytochrome P450, is of potential importance in toxicological and clinical studies.
P450 Binding (interaction) of associated with versed and lidocaine
11) Confidence 0.13 Published 2002 Journal Hum Exp Toxicol Section Abstract Doc Link 12412639 Disease Relevance 0.15 Pain Relevance 0.93
A few exceptions aside, there generally exists a qualitative relationship between the ability of P450 3As, induced by DEX, to bind and N-dealkylate amino compounds and their propensity to lead to 455 nm absorbing complexes.
P450 Binding (bind) of associated with dexamethasone
12) Confidence 0.11 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7887973 Disease Relevance 0 Pain Relevance 0.43
Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs.
P450 Binding (ability) of
13) Confidence 0.11 Published 1995 Journal Biochem. Pharmacol. Section Title Doc Link 7887973 Disease Relevance 0 Pain Relevance 0.35
Immunocytochemical localization using antibodies to P-450b,e indicated the presence of P-450 predominantly in the neuronal cell bodies and to a lesser extent in the fibre tracts in cerebral cortex, cerebellum, thalamus, hypothalamus, hippocampus and brainstem.
P-450 Binding (presence) of in thalamus associated with medulla, hippocampus, thalamus and cerebral cortex
14) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 2085761 Disease Relevance 0 Pain Relevance 0.27
Immunocytochemical localization using antibodies to P-450b,e indicated the presence of P-450 predominantly in the neuronal cell bodies and to a lesser extent in the fibre tracts in cerebral cortex, cerebellum, thalamus, hypothalamus, hippocampus and brainstem.
P-450 Binding (presence) of in cerebral cortex associated with medulla, hippocampus, thalamus and cerebral cortex
15) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 2085761 Disease Relevance 0 Pain Relevance 0.27
Immunocytochemical localization using antibodies to P-450b,e indicated the presence of P-450 predominantly in the neuronal cell bodies and to a lesser extent in the fibre tracts in cerebral cortex, cerebellum, thalamus, hypothalamus, hippocampus and brainstem.
P-450 Binding (presence) of in cerebellum associated with medulla, hippocampus, thalamus and cerebral cortex
16) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 2085761 Disease Relevance 0 Pain Relevance 0.27
Immunocytochemical localization using antibodies to P-450b,e indicated the presence of P-450 predominantly in the neuronal cell bodies and to a lesser extent in the fibre tracts in cerebral cortex, cerebellum, thalamus, hypothalamus, hippocampus and brainstem.
P-450 Binding (presence) of in hypothalamus associated with medulla, hippocampus, thalamus and cerebral cortex
17) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 2085761 Disease Relevance 0 Pain Relevance 0.27
Immunocytochemical localization using antibodies to P-450b,e indicated the presence of P-450 predominantly in the neuronal cell bodies and to a lesser extent in the fibre tracts in cerebral cortex, cerebellum, thalamus, hypothalamus, hippocampus and brainstem.
P-450 Binding (presence) of in brainstem associated with medulla, hippocampus, thalamus and cerebral cortex
18) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 2085761 Disease Relevance 0 Pain Relevance 0.27
Hepatic cytochrome P450 (P450) content and verapamil protein binding were also measured.
P450 Binding (binding) of
19) Confidence 0.01 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15659540 Disease Relevance 0.89 Pain Relevance 0.44
Cytochrome P450IIE was detected immunologically and enzymatically, using two activities associated with cytochrome P450IIE, p-nitrophenol hydroxylation, and acetaminophen activation to a metabolite that binds to glutathione.
P450IIE Binding (associated) of associated with paracetamol
20) Confidence 0.01 Published 1991 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 1989519 Disease Relevance 0.09 Pain Relevance 0.10

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