INT171472

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.79
Pain Relevance 4.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
spinal nerve 1
spinal 1
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 149 100.00 Very High Very High Very High
cytokine 47 100.00 Very High Very High Very High
antagonist 20 100.00 Very High Very High Very High
Etanercept 13 100.00 Very High Very High Very High
Spinal nerve ligature 3 100.00 Very High Very High Very High
cINOD 16 99.92 Very High Very High Very High
Central nervous system 39 98.76 Very High Very High Very High
Lasting pain 13 98.40 Very High Very High Very High
Neuropathic pain 10 98.28 Very High Very High Very High
allodynia 24 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 158 100.00 Very High Very High Very High
Apoptosis 120 99.82 Very High Very High Very High
Pain 56 98.40 Very High Very High Very High
Neuropathic Pain 34 98.28 Very High Very High Very High
Pressure And Volume Under Development 39 94.88 High High
Rheumatoid Arthritis 38 94.04 High High
Osteoarthritis 42 90.32 High High
Arthritis 28 89.36 High High
Hyperalgesia 20 89.24 High High
Stress 21 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its alpha and gamma isoforms are implicated in pathways leading to chronic inflammation [10]. p38 MAPK activates and interacts with immunomodulators such as signal transducer and activator of transcription 4 (STAT4), which has been recently associated with susceptibility to RA [11], other map kinase molecules (such as ERKs and MKKs), and NF?
p38 Binding (interacts) of associated with inflammation and rheumatoid arthritis
1) Confidence 0.36 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2235846 Disease Relevance 1.04 Pain Relevance 0.76
The current study identifies an intracellular mechanism, to our knowledge not yet described, that involves spinal p38 MAP kinase as a link between the periphery and the CNS.
p38 Binding (link) of in spinal associated with central nervous system
2) Confidence 0.35 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.47 Pain Relevance 0.69
Pretreatment of rats before spinal nerve ligation with the TNF antagonist etanercept (EnbrelĀ®) or cytokine inhibition by the p38 inhibitor SB-203580 demonstrated similar degrees of inhibition of mechanically induced allodynia [9].
p38 Binding (ligation) of in spinal nerve associated with allodynia, antagonist, spinal nerve ligature, etanercept and cytokine
3) Confidence 0.33 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 1.43 Pain Relevance 1.57
Lastly, a DNA damage protein (Gadd45a) and a MAP kinase (Mapk14), two other proteins recently associated with Wnt activation, were also differentially expressed in PB- and PTU-treated animals but not in NaI-treated animals (Hildesheim et al. 2004).
Mapk14 Binding (associated) of
4) Confidence 0.26 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.40 Pain Relevance 0
Conversely, the inappropriate persistence of enhanced glial marker expression and p38 phosphorylation is associated with the generation and maintenance of chronic pain states [30], [31].
p38 Binding (associated) of associated with lasting pain
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 1.15 Pain Relevance 0.91
the presence of insulin and stimulates p38 MAP-kinase and PI-3 kinase activity
p38 MAP-kinase Binding (activity) of
6) Confidence 0.14 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.55 Pain Relevance 0.06
Anti-inflammatory activity
Anti-inflammatory Binding (activity) of associated with inflammation
7) Confidence 0.05 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2990385 Disease Relevance 0.10 Pain Relevance 0.36
Many (Tran et al. 2001, Bortner & Cidlowski 2002, Ley et al. 2004), but not all (Wang et al. 2000, Zhuang & Schnellmann 2006), such studies have supported the general view that activation of the ERK pathway mediates survival signals which counteract pro-apoptotic effects associated with JNK and p38 activation.
p38 Binding (associated) of associated with apoptosis
8) Confidence 0.05 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.77 Pain Relevance 0.11
Anti-inflammatory activity
Anti-inflammatory Binding (activity) of associated with inflammation
9) Confidence 0.04 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113267 Disease Relevance 0.29 Pain Relevance 0.10
Anti-inflammatory activity
Anti-inflammatory Binding (activity) of associated with inflammation
10) Confidence 0.04 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113267 Disease Relevance 0.59 Pain Relevance 0.27

General Comments

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