INT1715

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Context Info
Confidence 0.70
First Reported 1979
Last Reported 2009
Negated 1
Speculated 3
Reported most in Abstract
Documents 51
Total Number 54
Disease Relevance 24.00
Pain Relevance 47.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Nrm) nucleus (Nrm)
Anatomy Link Frequency
neurons 18
tail 2
tooth pulp 2
spinal 2
visceral 1
Nrm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe magnus 431 100.00 Very High Very High Very High
Central grey 84 100.00 Very High Very High Very High
analgesia 56 100.00 Very High Very High Very High
Opioid 49 100.00 Very High Very High Very High
gABA 24 100.00 Very High Very High Very High
medulla 18 100.00 Very High Very High Very High
Inflammation 8 99.98 Very High Very High Very High
Dorsal horn 20 99.92 Very High Very High Very High
Morphine 152 99.90 Very High Very High Very High
electroacupuncture 51 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 113 100.00 Very High Very High Very High
INFLAMMATION 6 99.98 Very High Very High Very High
Abdominal Pain 2 99.84 Very High Very High Very High
Pain 83 99.74 Very High Very High Very High
Temporomandibular Joint Syndrome 8 99.72 Very High Very High Very High
Neuropathic Pain 16 99.64 Very High Very High Very High
Diarrhoea 9 99.46 Very High Very High Very High
Nociception 91 99.32 Very High Very High Very High
Injury 18 99.14 Very High Very High Very High
Rheumatoid Arthritis 6 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
"Yanglingquan" or "Zusanli" EA could also activate NRM and inhibit the nociceptive responses, but the inhibition on the nociceptive response of tail stimulation about -60-(-)40% for 30 minutes, P < 0.05-0.001) was stronger and longer than that of dental pulp (about -40% for 5-10 minutes, P < 0.05-0.001).
Positive_regulation (activate) of NRM in tail associated with nociception
1) Confidence 0.70 Published 1995 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7648703 Disease Relevance 0.72 Pain Relevance 0.09
We examined whether mechanical allodynia (cutaneous hypersensitivity) after incomplete SCI is sustainably reversed by prolonged, intermittent electrical stimulation of the NRM and whether altered NRM activity accounts for the allodynia.
Spec (whether) Positive_regulation (stimulation) of NRM associated with raphe magnus, allodynia, skin allergy and frailty
2) Confidence 0.61 Published 2009 Journal J Rehabil Res Dev Section Abstract Doc Link 19533524 Disease Relevance 1.23 Pain Relevance 0.77
The results showed that EA of "Shangguan" or "Xiaguan" could activate NRM, increasing unit discharges about 70-120% for 10-15 minutes (P < 0.05-0.001) and inhibit both nociceptive responses, but the inhibition on the nociceptive response induced by dental pulp (about -60% for 5-10 minutes, P < 0.05-0.001) was stronger than that by tail tip (no effect or about -30% occasionally).
Positive_regulation (activate) of NRM associated with nociception
3) Confidence 0.61 Published 1995 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7648703 Disease Relevance 0.73 Pain Relevance 0.11
EA of 'Zusanli' could activate NRM neurons, increasing spontaneous firing rates, and inhibit their nociceptive responses.
Positive_regulation (activate) of NRM in neurons associated with nociception and raphe magnus
4) Confidence 0.61 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2125870 Disease Relevance 0.17 Pain Relevance 0.79
These results suggest that activation of NRM can alleviate the renal pain as well as the somatic pain by modulating the dorsal horn neurons activities.
Positive_regulation (activation) of NRM in dorsal horn associated with pain, raphe magnus, somatic pain and dorsal horn neuron
5) Confidence 0.60 Published 1995 Journal Yonsei Med. J. Section Abstract Doc Link 7483678 Disease Relevance 0.45 Pain Relevance 1.09
It is concluded that: (1) in response to chemical stimulation of MPO, the number of I-cells that were inhibited was more than three times the number of I-cells that were excited; in contrast, the number of E-cells that were excited was more than twice the number of E-cells that were inhibited. (2) The interaction between MPO and NRM can be modulated by blockade of the neuronal transmission or blockade of the glutamatergic system in the PAG. (3) Simultaneous activity of many synapses is required for activation of the MPO-NRM pathway. (4) MPO to NRM interaction is mediated by fibers with a conduction velocity of less than 1m/s.
Positive_regulation (activation) of NRM in MPO associated with raphe magnus, urological neuroanatomy and central grey
6) Confidence 0.57 Published 2001 Journal Pain Section Abstract Doc Link 11690727 Disease Relevance 0.89 Pain Relevance 0.44
Stimulation at one of them can activate neuron of NRM, increasing firing rate, and induce analgesia.
Positive_regulation (activate) of NRM in neuron associated with raphe magnus and analgesia
7) Confidence 0.54 Published 1996 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 9387347 Disease Relevance 0.51 Pain Relevance 1.84
Our previous study has pointed that pain stimulation induced AVP increase in the nucleus raphe magnus (NRM), which plays a role in pain modulation.
Positive_regulation (increase) of NRM in nucleus associated with raphe magnus and pain
8) Confidence 0.52 Published 2009 Journal Peptides Section Abstract Doc Link 19520128 Disease Relevance 0.61 Pain Relevance 0.93
We conclude that LC actions in the spinal cord are mediated primarily through a pathway in the ipsilateral ventral quadrant whereas those from NRM are mediated through bilateral projections in DLF.
Positive_regulation (mediated) of NRM in spinal cord associated with raphe magnus, locus ceruleus and spinal cord
9) Confidence 0.50 Published 1986 Journal Exp Brain Res Section Abstract Doc Link 3007190 Disease Relevance 0.07 Pain Relevance 0.94
These results suggest that chronic morphine increases GABA synaptic activity through upregulation of the AMP system in morphine-tolerant NRM neurons and that while chronic GABA(A) receptor antagonism in the NRM augments morphine tolerance, chronic activation of NRM GABA(A) receptors or PKA inhibition reduces morphine tolerance with increased analgesic efficacy of chronic morphine.
Positive_regulation (activation) of NRM in neurons associated with raphe magnus, gaba, analgesic, tolerance and morphine
10) Confidence 0.49 Published 2006 Journal Pain Section Abstract Doc Link 16527406 Disease Relevance 0 Pain Relevance 2.64
However, inhibition of the tail-flick reflex produced by electrical stimulation in the NRM-MRF was eliminated by the local anesthetic.
Positive_regulation (stimulation) of NRM-MRF in MRF associated with raphe magnus, tail-flick and local anesthetic
11) Confidence 0.47 Published 1987 Journal Brain Res. Section Abstract Doc Link 3607431 Disease Relevance 0.19 Pain Relevance 0.94
Injection of glutamate and lidocaine into NRM demonstrated that these effects were due to activation of NRM neurons and not to current spread to medial lemniscus (ML).
Neg (not) Positive_regulation (activation) of NRM in neurons associated with raphe magnus, glutamate and lidocaine
12) Confidence 0.45 Published 1992 Journal J. Neurophysiol. Section Abstract Doc Link 1350307 Disease Relevance 0 Pain Relevance 0.51
We examined whether mechanical allodynia (cutaneous hypersensitivity) after incomplete SCI is sustainably reversed by prolonged, intermittent electrical stimulation of the NRM and whether altered NRM activity accounts for the allodynia.
Spec (whether) Positive_regulation (accounts) of NRM associated with raphe magnus, allodynia, skin allergy and frailty
13) Confidence 0.44 Published 2009 Journal J Rehabil Res Dev Section Abstract Doc Link 19533524 Disease Relevance 1.25 Pain Relevance 0.77
Single-cell extracellular recording 12 to 14 weeks after thoracic contusion injury revealed generally higher spontaneous firing and weaker responses to above-injury noxious stimulation in both inhibited and excited NRM neurons; unresponsive neurons were fewer.
Positive_regulation (excited) of NRM in neurons associated with raphe magnus, injury and contusions
14) Confidence 0.44 Published 2009 Journal J Rehabil Res Dev Section Abstract Doc Link 19533524 Disease Relevance 1.56 Pain Relevance 0.92
Secondary aims were to estimate the percentage of patients who were high responders to NRM and to study the association of baseline patient characteristics with both high analgesic responsivity and the need of opioid dose escalation.
Positive_regulation (responders) of NRM associated with analgesic, opioid and morphine
15) Confidence 0.43 Published 2009 Journal Clin J Pain Section Abstract Doc Link 19454871 Disease Relevance 0.15 Pain Relevance 0.89
But the activities by a squeeze, a type of noxious stimuli, the activities were reduced to 63.2 +/- 7.2% of the control value. 3) After an electrical stimulation of NRM, activities of dorsal horn neurons with renal input evoked by occlusion of ureter or renal artery were reduced to 46.7 +/- 8.8% and 49.0 +/- 8.0% of the control value respectively. 4) The inhibitory effect of NRM on the dorsal horn neurons with renal input did not show any difference between renal A delta fiber and C fiber group. 5) By the electrical stimulation of NRM, the activities evoked by ureteral occlusion showed more reduction in the high threshold cell group than in the wide dynamic range cell group.
Positive_regulation (stimulation) of NRM in cell group associated with c fibre, raphe magnus, wide dynamic range and dorsal horn neuron
16) Confidence 0.43 Published 1995 Journal Yonsei Med. J. Section Abstract Doc Link 7483678 Disease Relevance 0.27 Pain Relevance 1.11
After lesion of bilateral larger areas of SM, the effects of EA on 14 neurons in NRM did not show activation of NRM neurons, but EA could still inhibit their nociceptive responses of the neurons in 5-25 minutes (P less than 0.01).
Positive_regulation (activation) of NRM in neurons associated with nociception, raphe magnus and electroacupuncture
17) Confidence 0.41 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2118007 Disease Relevance 0.41 Pain Relevance 0.81
We tested whether fentanyl activates NRM neurons in the rat slice preparation using extra-cellular recording.
Spec (whether) Positive_regulation (activates) of NRM in neurons associated with raphe magnus
18) Confidence 0.41 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7726430 Disease Relevance 0.09 Pain Relevance 0.64
Overall, 62% of the cells tested (48/78) were responsive to electrical stimulation of the NRM with the predominant response being inhibitory (38/48; 79%).
Positive_regulation (stimulation) of NRM associated with raphe magnus
19) Confidence 0.41 Published 1994 Journal Pharmacology Section Abstract Doc Link 8309982 Disease Relevance 0.16 Pain Relevance 0.69
Iontophoretic application of acetylcholine also activates NRM neurons and microinjection of cholinergic agonists such as carbachol into the NRM produces a profound, long-lasting antinociception.
Positive_regulation (activates) of NRM in neurons associated with antinociception, raphe magnus and agonist
20) Confidence 0.41 Published 1986 Journal Brain Res. Section Abstract Doc Link 3708347 Disease Relevance 0 Pain Relevance 1.22

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