INT171514

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Context Info
Confidence 0.32
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.32
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EP300) transferase activity, transferring acyl groups (EP300) DNA binding (EP300)
cytoplasm (EP300) nucleolus (EP300) nucleus (EP300)
Anatomy Link Frequency
liver 1
hematopoietic system 1
B cells 1
colon 1
lobe 1
EP300 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 118 99.30 Very High Very High Very High
methadone 106 97.20 Very High Very High Very High
alcohol 106 97.16 Very High Very High Very High
addiction 75 96.84 Very High Very High Very High
Opioid 45 91.84 High High
agonist 58 88.32 High High
cannabis 12 87.20 High High
rheumatoid arthritis 78 83.84 Quite High
antagonist 22 83.20 Quite High
cocaine 10 81.92 Quite High
Disease Link Frequency Relevance Heat
Cancer 408 99.76 Very High Very High Very High
Antisocial Personality Disorder 1 99.46 Very High Very High Very High
Attention Deficit And Disruptive Behavior Disorders 1 98.72 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 4 98.36 Very High Very High Very High
Conduct Disorder 1 97.26 Very High Very High Very High
Alcohol Addiction 79 97.16 Very High Very High Very High
Chronic Lymphoid Leukemia 7 95.64 Very High Very High Very High
Apoptosis 67 92.00 High High
Nicotine Addiction 50 91.52 High High
Esophageal Cancer 33 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P300 evoked potential recording
P300 Binding (recording) of
1) Confidence 0.32 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0.16 Pain Relevance 0.58
Among controls, nicotine consumption had a major impact on P300 amplitudes with a significant group effect (p < 0.001) but no significant electrode × group interaction.
P300 Neg (no) Binding (interaction) of associated with nicotine
2) Confidence 0.31 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2198909 Disease Relevance 0 Pain Relevance 0.51
CREB-binding protein and p300) are associated with cancers of the breast, colon, liver, and hematopoietic system.
p300 Binding (associated) of in hematopoietic system associated with cancer
3) Confidence 0.26 Published 2007 Journal Bioinform Biol Insights Section Body Doc Link PMC2323355 Disease Relevance 0.40 Pain Relevance 0
Selective recruitment of p300 or CBP has indeed been shown to be required for selective activation of p21Cip1 and of p27Kip1 genes respectively [14].
p300 Binding (recruitment) of
4) Confidence 0.14 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0
In the absence of this allele, the binding of EP300 to this region is predicted to be disrupted, potentially disturbing the epigenetic tag for transcriptional activation.
EP300 Binding (binding) of
5) Confidence 0.10 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1976626 Disease Relevance 0.53 Pain Relevance 0.20
P300 is associated with frontal lobe functioning and can be elicited by presenting the participant with a visual or auditory stimulus that is either unexpected or highly relevant for the task at hand [78].
P300 Binding (associated) of in lobe
6) Confidence 0.10 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.35 Pain Relevance 0.03
CREB-binding protein and p300) are associated with cancers of the breast, colon, liver, and hematopoietic system.
p300 Binding (associated) of in colon associated with cancer
7) Confidence 0.09 Published 2007 Journal Bioinform Biol Insights Section Body Doc Link PMC2323355 Disease Relevance 0.40 Pain Relevance 0
CREB-binding protein and p300) are associated with cancers of the breast, colon, liver, and hematopoietic system.
p300 Binding (associated) of in liver associated with cancer
8) Confidence 0.09 Published 2007 Journal Bioinform Biol Insights Section Body Doc Link PMC2323355 Disease Relevance 0.40 Pain Relevance 0
forms an active complex with the transcriptional coactivator p300 and activated Stat3 on the VEGF promoter, which likely explains the anomalous autocrine VEGF secretion from CLL B cells [273].
p300 Binding (complex) of in B cells associated with chronic lymphoid leukemia
9) Confidence 0.08 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.80 Pain Relevance 0.15
In mammalian cells, CBP/P300 can also act as a co-activator of ?
P300 Binding (act) of
10) Confidence 0.06 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.47 Pain Relevance 0
CBP or its closely related homolog p300 were initially identified in protein interaction assays, first through their association with the transcription factor CREB [172] and later through their interaction with the adenoviral-transforming protein E1A [173].
p300 Binding (interaction) of
11) Confidence 0.06 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0.08
This variation was observed in several desinhibitory disorders, such as conduct disorder, attention-deficit hyperactivity disorder, oppositional defiant disorder, and antisocial personality disorder [98], suggesting that the P300 is associated with an intermediate phenotype, such as impulsivity, rather than with alcohol dependence itself.


P300 Binding (associated) of associated with addiction, conduct disorder, antisocial personality disorder, attention deficit and disruptive behavior disorders, attention deficit hyperactivity disorder and alcohol
12) Confidence 0.05 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691669 Disease Relevance 0.82 Pain Relevance 0.46
Both p300 and CBP can mediate acetylation of Rch1 and importin-?
p300 Binding (mediate) of
13) Confidence 0.05 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0

General Comments

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