INT171528

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Context Info
Confidence 0.07
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.47
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREBBP) small molecule metabolic process (CREBBP) protein complex assembly (CREBBP)
DNA binding (CREBBP) cytoplasm (CREBBP) signal transducer activity (CREBBP)
Anatomy Link Frequency
nucleus 2
CREBBP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 30 84.60 Quite High
Potency 4 25.56 Quite Low
Kinase C 24 16.40 Low Low
cINOD 52 5.00 Very Low Very Low Very Low
aspirin 28 5.00 Very Low Very Low Very Low
agonist 13 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
diclofenac 4 5.00 Very Low Very Low Very Low
cOX1 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 74 92.16 High High
Repression 6 80.20 Quite High
Cancer 326 73.84 Quite High
Solid Tumor 4 70.24 Quite High
Carcinoma 8 53.24 Quite High
Colon Cancer 40 49.60 Quite Low
Adenoma 8 42.72 Quite Low
Reprotox - General 1 1 38.32 Quite Low
Malignant Neoplastic Disease 8 32.60 Quite Low
Adhesions 12 26.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective recruitment of p300 or CBP has indeed been shown to be required for selective activation of p21Cip1 and of p27Kip1 genes respectively [14].
CBP Binding (recruitment) of
1) Confidence 0.07 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC113761 Disease Relevance 0 Pain Relevance 0
-catenin is then able to localize to the nucleus [15], form a complex with Tcf/Lef transcription factors and co-activators such as (CREB Binding Protein, CBP) [16, 17] and induce the expression of downstream target genes (see http://www.stanford.edu/~rnusse/wntwindow.html).
CREB Binding Protein Binding (complex) of in nucleus
2) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0
CBP or its closely related homolog p300 were initially identified in protein interaction assays, first through their association with the transcription factor CREB [172] and later through their interaction with the adenoviral-transforming protein E1A [173].
CBP Binding (interaction) of
3) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0.08
In mammalian cells, CBP/P300 can also act as a co-activator of ?
CBP Binding (act) of
4) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.47 Pain Relevance 0
-catenin is then able to localize to the nucleus [15], form a complex with Tcf/Lef transcription factors and co-activators such as (CREB Binding Protein, CBP) [16, 17] and induce the expression of downstream target genes (see http://www.stanford.edu/~rnusse/wntwindow.html).
CBP Binding (complex) of in nucleus
5) Confidence 0.05 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0
Both p300 and CBP can mediate acetylation of Rch1 and importin-?
CBP Binding (mediate) of
6) Confidence 0.02 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0

General Comments

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